G Bendle
Imperial College London
9 Papers
142 Citations
G Bendle is an academic researcher from Imperial College London. The author has contributed to research in topics: Cytotoxic T cell & T cell. The author has an hindex of 6, co-authored 9 publications. Previous affiliations of G Bendle include University College London.
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Papers
Induction of Unresponsiveness Limits Tumor Protection by Adoptively Transferred MDM2-Specific Cytotoxic T Lymphocytes
G Bendle,Angelika Holler,Luke-Kwok Pang,Stephen Hsu,Mauro Krampera,Elizabeth Simpson,Hans J. Stauss +6 more
TL;DR: It is shown that tumor growth occurred despite the continued presence of MDM2-specific CTLs and the continued susceptibility of tumor cells to CTL killing, and experiments suggest that induction of unresponsiveness may be an important mechanism limiting the efficacy of adoptive CTL therapy.
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Prospects for immunotherapy of malignant disease
TL;DR: Transfer of HLA‐restricted antigen receptors provides an opportunity to empower patient T cells with new tumour‐reactive specificities that cannot be retrieved from the autologous T cell repertoire.
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CD8α/α homodimers fail to function as co-receptor for a CD8-dependent TCR
Anne-Marie McNicol,G Bendle,Angelika Holler,Theres Matjeka,Emma Dalton,Lorna Rettig,Rose Zamoyska,Wolfgang Uckert,Shao-An Xue,Hans J. Stauss +9 more
TL;DR: Data indicate a striking difference between CD8 α/β heterodimers and CD8α/α homodimer as only the former were able to provide co‐receptor function for the CD8‐dependent TCR, which triggered antigen‐specific cytotoxicity in wild‐type T cells.
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WT1-targeted immunotherapy of leukaemia.
Shao-An Xue,Liquan Gao,Roopinder Gillmore,G Bendle,A. Holler,A.‐M. Downs,A Tsallios,Francisco Ramirez,Yasmeen Ghani,Daniel P. Hart,S. Alcock,A. Tranter,Hans J. Stauss,Emma C. Morris +13 more
TL;DR: TCR gene transfer can be used to take advantage of the specificity of allorestricted CTL and transfer it to patient CTL, while avoiding the transfer of immunogenic alloantigens from the donor CTL to the patient.
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Broadly expressed tumour-associated proteins as targets for cytotoxic T lymphocyte-based cancer immunotherapy.
TL;DR: This review analyses the level of tolerance to broadly expressed tumour-associated proteins in the autologous T cell repertoire, assesses strategies that have been developed to circumvent T cell tolerance to such antigens, and evaluates the prospects for effective immunotherapy targeting broadly expressed cancer proteins.
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