22 Papers
402 Citations
G. Baj is an academic researcher from University of Eastern Piedmont. The author has contributed to research in topics: Signal transduction & CD38. The author has an hindex of 14, co-authored 22 publications. Previous affiliations of G. Baj include University of Turin.
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Papers
Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT
Gianluca Baldanzi,Nicoletta Filigheddu,Santina Cutrupi,Filomena Catapano,Sara Bonissoni,Alberto Fubini,Daniela Malan,G. Baj,Riccarda Granata,Fabio Broglio,Mauro Papotti,Nicola Surico,Federico Bussolino,Jörgen Isgaard,Romano Deghenghi,Fabiola Sinigaglia,Maria Prat,Giampiero Muccioli,Ezio Ghigo,Andrea Graziani +19 more
TL;DR: These findings provide the first evidence that, independent of its acylation, ghrelin gene product may act as a survival factor directly on the cardiovascular system through binding to a novel, yet to be identified receptor, which is distinct from GHSR-1a.
Signaling through CD38 induces NK cell activation.
Roberto Mallone,Ada Funaro,Mercedes Zubiaur,G. Baj,Clara M. Ausiello,Carlo Tacchetti,Jaime Sancho,Carlo E. Grossi,Fabio Malavasi +8 more
TL;DR: The results suggest that the activation signals transduced by CD38 in NK cells elicit relevant cellular events that are similar to those elicited via CD16 and possibly rely on common signaling pathways.
Human anti-CD38 autoantibodies raise intracellular calcium and stimulate insulin release in human pancreatic islets.
Alessandro Antonelli,G. Baj,Piero Marchetti,Poupak Fallahi,Nicola Surico,Cinzia Pupilli,Fabio Malavasi,Ele Ferrannini +7 more
TL;DR: It is concluded that human anti-CD38 autoantibodies with agonistic properties on the CD38 effector system occur in nature; in human islets, their [Ca2+]i-mobilizing activity is coupled with the ability to stimulate insulin release.
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Evidence of an immunologic mechanism behind the therapeutical effects of arsenic trioxide (As2O3) on myeloma cells
TL;DR: Findings indicate that As(2)O(3) may be useful to boost the immune system against myelomas.
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