Resonance Energy Transfer: Methods and Applications

A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.

/pdf/peptide-nucleic-acids-1hpyrn4znw.pdf

Peptide nucleic acids

In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucleotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein.

Human monoclonal antibodies to CTLA-4

The invention provides fast and highly accurate mass spectrometer based processes for detecting a particular nucleic acid sequence in a biological sample. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromosomal abnormality; a predisposition to a disease or condition, infection by a pathogenic organism, or for determining identity or heredity.

DNA diagnostics based on mass spectrometry

The invention provides a composition whose porosity, pore size, pore connectivity, swelling agent concentration, and/or specific volume undergoes a change from a first value to a second value in response to an electromagnetic signal, the composition having a matrix material in which is distributed a magnetic material.

https://www.pnas.org/content/pnas/108/1/67.full.pdf

Active scaffolds for on-demand drug and cell delivery

T. Brown & D.J.S. Brown: Modern machine-aided methods of oligodeoxyribonucleotide synthesis M. Gait, C. Prichard & G. Slim: Oligoribonucleotide synthesis B. Sproat: 2'-O-methyl oligoribonucleotides G. Zon & W.J. Stec: Phosphorothioate oligonucleotides P. Miller, C.D. Cushman & J.T. Lewis: Methylphosphonate oligonucleotides B. Connolly: Oligonucleotides with modified bases N.D. Sinha & S. Streipeke: Oligonucleotides with reporter groups attached to the 5' terminus Prof D. McLaughlin et al: Oligodeoxynucleotides with reporter groups attached via the phosphate backbone Prof L. McLaughlin et al: Oligonucleotides for affinity chromatography J. Ruth: Oligonucleotides with reporter groups attached via the base N.T. Thuong & U. Asseline: Oligonucleotides attached to intercalators, photoreactive agents and cleavage agents.

Oligonucleotides and analogues : a practical approach

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Oligonucleotides and analogues : a practical approach