When the posture was changed from horizontal to vertical, or the reverse, the alteration in plasma volume and in the levels of haematocrit, haemoglobin, and plasma protein was much greater in patients with oedema or low plasma protein or albumin concentrations (“the pathological group”) than in patients without these abnormalities (“the control group”). This larger fluid shift, and the larger concentration changes dependent on it, are explained in terms of Starling9s hypothesis. In the control group there was scarcely any change in the total mass of intravascular plasma protein with change in posture, but in the pathological group this was often considerable. This was interpreted as indicating increased permeability of the capillaries to protein. Attention is drawn to the influence of uncontrolled alterations in posture on biochemical and haematological measurements and a recommendation is made in order to standardize conditions before taking blood for the analysis of non-diffusible constituents.

https://jcp.bmj.com/content/jclinpath/13/4/304.full.pdf

Effects of posture on plasma volume and some blood constituents.

The apparent usefulness of cortisone and ACTH in the treatment of acute rheumatic fever and rheumatic carditis was first pointed out by Hench and his associates1 shortly after they had reported the...

ACTH and Cortisone Therapy of Rheumatic Fever and Rheumatic Carditis

"eugenics: galton and after "

Studies of 17-hydroxycorticosteroids

https://jamanetwork.com/HttpHandlers/ArticlePdfHandler.ashx?journal=ophth&articleId=623410&pdfFileName=archopht_50_2_010.pdf

Pharmacology and toxicology

bf events ? Why does the cardiac patient pass into a dying state with a resting minute volume of circulation the same as that of an upright soldier ? The realization of ignorance brings its gleam of hope that continued research will add to our therapeutic power: cardiac surgery and new technical developments in investigation are adding daily to our knowledge and extending our experience in depth. In time some of the pictures crudely sketched in these lectures will be more clearly perceived, and be submitted once again to a much more rational and complete interpretation than we can give to-day.

/pdf/rheumatic-fever-some-observations-on-a-c-t-h-cortisone-and-4rjewfbcto.pdf

Rheumatic fever; some observations on A.C.T.H., cortisone, and salicylate therapy.

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Rheumatic fever; some observations on A.C.T.H., cortisone, and salicylate therapy.