Frederike Sass
University of Hamburg
9 Papers
10 Citations
Frederike Sass is an academic researcher from University of Hamburg. The author has contributed to research in topics: Brown adipose tissue & Adipose tissue. The author has an hindex of 4, co-authored 6 publications.
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Papers
Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation.
Alexander W. Fischer,Alexander W. Fischer,Michelle Y. Jaeckstein,Kristina Gottschling,Markus Heine,Frederike Sass,N. Mangels,Christian Schlein,Anna Worthmann,Oliver T. Bruns,Yucheng Yuan,Hua Zhu,Ou Chen,Harald Ittrich,Stefan K. Nilsson,Patrik Stefanicka,Jozef Ukropec,Miroslav Balaz,Hua Dong,Wenfei Sun,Rudolf Reimer,Ludger Scheja,Joerg Heeren +22 more
TL;DR: In this article, vascular endothelial cells in adipose tissues endocytose substantial amounts of triglyceride-rich lipoproteins (TRL) particles, which subsequently follow the endosomal-lysosomal pathway, where they undergo lysosomal acid lipase (LAL)-mediated processing.
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Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response
Goda Snieckute,Aitana Victoria Genzor,Anna Vind,Laura Ryder,Mark Stoneley,Sébastien Chamois,René Dreos,Cathrine Nordgaard,Frederike Sass,Melanie Blasius,Aida Rodríguez López,Sólveig H. Brynjólfsdóttir,Kasper L. Andersen,Anne E. Willis,Lisa B. Frankel,Steen Seier Poulsen,David Gatfield,Zachary Gerhart-Hines,Christoffer Clemmensen,Simon Bekker-Jensen +19 more
TL;DR: In this article , it was shown that stalling of ribosomes is sufficient to activate MAP3K ZAKα, which leads to activation of p38 and JNK kinases.
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ROS-induced ribosome impairment underlies ZAKα-mediated metabolic decline in obesity and aging
Goda Snieckute,Laura Ryder,Anna Vind,Zhenzhen Wu,Frederic S Arendrup,Mark Stoneley,Sébastien Chamois,Ana Martinez-Val,Marion Leleu,René Dreos,Alexander Russell,David Michael Gay,Aitana Victoria Genzor,Béatrice S.-Y. Choi,Astrid L. Basse,Frederike Sass,Morten Dall,Lucile Chantal Marie Dollet,Melanie Blasius,Anne E Willis,Anders H Lund,Jonas T. Treebak,Jesper V. Olsen,Steen Seier Poulsen,Mary Elizabeth Pownall,Benjamin Anderschou Holbech Jensen,Christoffer Clemmensen,Zach Gerhart-Hines,David Gatfield,Simon Bekker-Jensen +29 more
TL;DR: It is shown that reactive oxygen species (ROS)–generating agents trigger ribosomal impairment and ZAKα activation, and that ROS activates the RSR in cellular models, associated with both stalling and collision of ribosomes.
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Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution
Christian Schlein,Alexander W. Fischer,Frederike Sass,Anna Worthmann,Klaus Tödter,Michelle Y. Jaeckstein,Janina Behrens,Matthew D. Lynes,Michael A. Kiebish,Niven R. Narain,Val Bussberg,Abena Darkwah,Naja Z. Jespersen,Søren Nielsen,Camilla Scheele,Michaela Schweizer,Ingke Braren,Alexander Bartelt,Yu-Hua Tseng,Joerg Heeren,Ludger Scheja +20 more
TL;DR: Using metabolic and lipidomic approaches, this article showed that endogenous fatty acid synthesis, regulated by carbohydrate-response element-binding protein (ChREBP), is the central regulator of brown adipose tissue (BAT) involution, characterized by decreased mitochondrial mass and increased lipid deposition.
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The anorectic and thermogenic effects of pharmacological lactate in male mice are confounded by treatment osmolarity and co-administered counterions
Jens Lund,Alberte Wollesen Breum,C. Gil,Sarah Falk,Frederike Sass,Marie S. Isidor,Oksana Dmytriyeva,Pablo Ranea-Robles,C. V. Mathiesen,Astrid L. Basse,O. S. Johansen,Nicole Fadahunsi,Camilla Lund,Trine S. Nicolaisen,Anders B. Klein,Brice Emanuelli,Maximilian Kleinert,Charlotte Mehlin Sorensen,Zachary Gerhart-Hines,Christoffer Clemmensen +19 more
TL;DR: It is shown that the hypertonicity of the injected solutions can drive the metabolic effects attributed to pharmacological administration of lactate, and the importance of taking treatment osmolarity and counterions into account in the experimental design is highlighted.
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