Perinatal Understanding of Mindful Awareness for Sleep (PUMAS): A single-arm proof-of-concept clinical trial of a mindfulness-based intervention for DSM-5 insomnia disorder during pregnancy.

Abstract Objectives Combining mindfulness with behavioral sleep strategies has been found to alleviate symptoms of insomnia and depression during pregnancy, but mechanisms for this treatment approach remain unclear. The present study examined nocturnal cognitive arousal and sleep effort as potential treatment mechanisms for alleviating insomnia and depression via a mindfulness sleep program for pregnant women. Methods Secondary analysis from a proof-of-concept trial of 12 pregnant women with DSM-5 insomnia disorder who were treated with Perinatal Understanding of Mindful Awareness for Sleep (PUMAS), which places behavioral sleep strategies within a mindfulness framework. Data were collected across eight weekly assessments: pretreatment, six sessions, and posttreatment. Measures included the insomnia severity index (ISI), Edinburgh postnatal depression scale (EPDS), pre-sleep arousal scale’s cognitive factor (PSASC), and the Glasgow sleep effort scale (GSES). We used linear mixed modeling to test cognitive arousal and sleep effort as concurrent and prospective predictors of insomnia and depression. Results Most patients reported high cognitive arousal before PUMAS (75.0%), which decreased to 8.3% after treatment. All insomnia remitters reported low cognitive arousal after treatment, whereas half of nonremitters continued reporting high cognitive arousal. Both nocturnal cognitive arousal and sleep effort were associated with same-week changes in insomnia throughout treatment, and sleep effort yielded a prospective effect on insomnia. Lower levels of nocturnal cognitive arousal and sleep effort prospectively predicted reductions in depression. Conclusions The present study offers preliminary evidence that reducing sleep effort and nocturnal cognitive arousal may serve as key mechanisms for alleviating insomnia and depression via mindfulness-based insomnia therapy. ClinicalTrials.gov ID: NCT04443959

Reducing cognitive arousal and sleep effort alleviates insomnia and depression in pregnant women with DSM-5 insomnia disorder treated with a mindfulness sleep program

OBJECTIVE
To identify sleep characteristics and factors associated with sleep issues during pregnancy.


METHOD
This is a longitudinal, with three follow-up periods at each gestational trimester (called T1, T2 and T3). Fifty (50) pregnant women without comorbidities started the study. The following instruments were used: sociodemographic and clinical characterization, Pittsburgh Sleep Quality Index and Sleep Diary. Data were analyzed using statistical tests (Chi-square, non-parametric tests and regression models).


RESULTS
We identified that 55.3% of the pregnant women reported sleep disorders in T1, 39.5% in T2, and 65.8% in T3; in T3, the risk of reporting sleep problems increased by 67% in comparison with T2.


CONCLUSION
Considering the high prevalence of poor-quality sleep, especially in the third trimester, prenatal care is understood as a moment of intense learning and an opportunity for nurses to develop actions concerning education, guidance and sleep hygiene.

Sleep in pregnancy quarters: a longitudinal study.

RESUMO Objetivo: Identificar as características do sono e os fatores associados ao sono de má qualidade ao longo dos trimestres gestacionais. Método: Estudo longitudinal, quantitativo, com três períodos de acompanhamento, nos trimestres gestacionais (denominados T1, T2 e T3). Estudo longitudinal com 50 gestantes sem comorbidades. Utilizou-se os instrumentos: caracterização sociodemográfica e clínica, Índice de Qualidade do Sono de Pittsburgh e Diário de Sono. Os dados foram analisados por testes estatísticos (Qui-quadrado, testes não paramétricos e modelos de regressão). Resultados: Identificou-se que 55,3% das gestantes relataram sono de má qualidade em T1, 39,5% em T2 e 65,8% em T3 e que, em T3, houve 67% a mais de risco de relatos de sono de má qualidade do que em T2. Conclusão: Considerando-se a elevada prevalência de má qualidade do sono, principalmente no terceiro trimestre, compreende-se o pré-natal como um momento de aprendizado e oportunidade para os enfermeiros desenvolverem ações de educação, orientação e higiene do sono.

O sono nos trimestres gestacionais: um estudo longitudinal

Abstract Study objectives Sleep disruption is common in pregnancy, manifesting as insomnia in half of pregnant women as well as increasing objective nocturnal wakefulness across gestation. Despite potential overlap between insomnia and objective sleep disturbances in pregnancy, objective nocturnal wakefulness and its potential contributing factors remain uncharacterized in prenatal insomnia. The present study described objective sleep disturbances in pregnant women with insomnia and identified insomnia-related predictors of objective nocturnal wakefulness. Methods Eighteen pregnant women with clinically significant insomnia symptoms (n = 12/18 with DSM-5 insomnia disorder) underwent two overnight polysomnography (PSG) studies. Insomnia symptoms (Insomnia Severity Index), depression and suicidal ideation (Edinburgh Postnatal Depression Scale), and nocturnal cognitive arousal (Pre-Sleep Arousal Scale, Cognitive factor) were assessed before bedtime on each PSG night. Unique to Night 2, participants were awakened after 2 minutes of N2 sleep and reported their in-lab nocturnal (i.e. pre-sleep) cognitive arousal. Results Difficulty maintaining sleep was the most common objective sleep disturbance affecting 65%–67% of women across both nights, which contributed to short and inefficient sleep. Nocturnal cognitive arousal and suicidal ideation were the most robust predictors of objective nocturnal wakefulness. Preliminary evidence suggested nocturnal cognitive arousal mediates the effects of suicidal ideation and insomnia symptoms on objective nocturnal wakefulness. Conclusions Nocturnal cognitive arousal may facilitate upstream effects of suicidal ideation and insomnia symptoms on objective nocturnal wakefulness. Insomnia therapeutics reducing nocturnal cognitive arousal may benefit objective sleep in pregnant women presenting with these symptoms.

https://academic.oup.com/sleepadvances/advance-article-pdf/doi/10.1093/sleepadvances/zpad016/49443673/zpad016.pdf

A two-night polysomnography preliminary study in pregnant women with insomnia: suicidal ideation and nocturnal cognitive arousal prospectively predict objective nocturnal wakefulness

Background Poor sleep is common during pregnancy and is associated with increased risk of negative health outcomes. Research indicates that physical discomfort and having an active mind are primary factors for prenatal sleep disturbances. Mindfulness-based interventions have the potential for addressing these factors, but have yet to be optimized for this purpose in this population. Objective The objective of this study was to gather input from pregnant and postpartum individuals about the value of a mindfulness-based program for improving prenatal sleep and their preferred content and delivery format. Methods We conducted 2 focus groups with 12 pregnant people experiencing poor sleep quality and 3 individual interviews with postpartum people. Interviews were thematically analyzed. Results The majority of participants expressed strong interest in a mindfulness program for improving prenatal sleep. Participants reported that pregnancy-specific physical discomfort and worry (both general and pregnancy-specific) affected their sleep. Participants wanted sleep education, and strategies for calming the mind, reducing physical discomfort, reducing impact of bedtime partners on sleep, and tips for improving sleep schedule and quality. Participants recognized the convenience of an online intervention and the social benefits of an in-person intervention and favored a hybrid delivery model. Conclusion Addressing prenatal sleep problems is an unmet need. Given the challenges and discomfort women face during pregnancy, and the importance of adequate sleep for promoting mental and physical health during pregnancy, sleep difficulties are critical to address. A mindfulness-based intervention for improving prenatal sleep was deemed of high interest to this perinatal population.

Examining Experiences of Poor Sleep During Pregnancy: A Qualitative Study to Inform the Development of a Prenatal Sleep Intervention

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Examining Experiences of Poor Sleep During Pregnancy: A Qualitative Study to Inform the Development of a Prenatal Sleep Intervention