Frédéric Legros
Centre national de la recherche scientifique
6 Papers
27 Citations
Frédéric Legros is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Metathesis & Heck reaction. The author has an hindex of 4, co-authored 6 publications.
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Papers
Stereospecific C-Glycosylation by Mizoroki-Heck Reaction: A Powerful and Easy-to-Set-Up Synthetic Tool to Access α- and β-Aryl-C-Glycosides.
Thibaud Mabit,Thibaud Mabit,Aymeric Siard,Frédéric Legros,Stéphane Guillarme,Arnaud Martel,Jacques Lebreton,François Carreaux,Gilles Dujardin,Sylvain Collet +9 more
TL;DR: A stereospecific Mizoroki-Heck cross-coupling of differently substituted glycals with haloarenes resulting in the exclusive formation of either α- or β-aryl-C-glycosides depending solely on the configuration at C3 was achieved, opening up new horizons for the total synthesis of glycosylated natural products.
α-Triethylsilyl-α-diazoacetone in double cross-aldolisation: convenient acetone equivalent toward 5-hydroxy-1,3-diketones
Anthony Lancou,Heloua Haroun,Uday Kumar Kundu,Frédéric Legros,Nicolas Zimmermann,Monique Mathé-Allainmat,Jacques Lebreton,Gilles Dujardin,Catherine Gaulon-Nourry,Pascal Gosselin +9 more
TL;DR: The diazo group could be efficiently removed by treatment with rhodium acetate to afford the corresponding 5-hydroxy-1,3-diketones as discussed by the authors.
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Function-Oriented Synthesis toward Peloruside A Analogues
Anne-Caroline Chany,Frédéric Legros,Heloua Haroun,Uday Kumar Kundu,Bohdan Biletskyi,Sergii Torlak,Monique Mathé-Allainmat,Jacques Lebreton,Aurélie Macé,Bertrand Carboni,Brigitte Renoux,Pascal Gosselin,Gilles Dujardin,Catherine Gaulon-Nourry +13 more
TL;DR: A convergent and rapid synthesis of original C2,C3-unsaturated, C11,C13-keto-enol macrocycles with a peloruside A skeleton with antiproliferative activity in the low micromolar range on NCI and MCF7 tumor cell lines is developed.
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Advances in the TBAF-induced aldol-type addition of α-trialkylsilyl-α-diazoacetones: TIPS versus TES
Imen Abid,Sigrid Gavelle,Anne-Caroline Chany,Frédéric Legros,Pascal Gosselin,Souhir Abid,Gilles Dujardin,Catherine Gaulon-Nourry +7 more
TL;DR: The robustness of TIPS-diazoacetone makes it a promising building block for the convergent elaboration of highly functionalised versatile diazocarbonyl compounds.
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Iconography : Advances in the TBAF-induced aldol-type addition of ?-trialkylsilyl-?-diazoacetones: TIPS versus TES
Imen Abid,Sigrid Gavelle,Anne-Caroline Chany,Frédéric Legros,Pascal Gosselin,Souhir Abid,Gilles Dujardin,Catherine Gaulon-Nourry +7 more
- 20 Jan 2017
TL;DR: Comptes Rendus Chimie - In Press. Available online since vendredi 20 janvier 2017 as mentioned in this paper, with proof corrected by the author available online since 20 Januaryvier 2017