Frédéric Jehan
French Institute of Health and Medical Research
30 Papers
446 Citations
Frédéric Jehan is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Nerve growth factor & Vitamin D and neurology. The author has an hindex of 20, co-authored 28 publications. Previous affiliations of Frédéric Jehan include Paris Diderot University & Paris Descartes University.
Chat about Author
Papers
Promoter and 3′-Untranslated-Region Haplotypes in the Vitamin D Receptor Gene Predispose to Osteoporotic Fracture: The Rotterdam Study
Yue Fang,Joyce B. J. van Meurs,Arnold d'Alesio,Mila Jhamai,Hongyan Zhao,Fernando Rivadeneira,Albert Hofman,Johannes P.T.M. van Leeuwen,Frédéric Jehan,Huibert A. P. Pols,André G. Uitterlinden +10 more
TL;DR: This comprehensive candidate-gene analysis demonstrates that the risk allele of multiple VDR polymorphisms results in lower VDR mRNA levels, which could impact the vitamin D signaling efficiency and might contribute to the increased fracture risk the authors observed for these risk haplotype alleles.
1,25-dihydroxyvitamin D3 is a potent inducer of nerve growth factor synthesis
TL;DR: 1,25‐(OH)2D3 could represent one of the serum factors that might contribute to the regulation of the NGF gene in vitro and possibly in vivo and is shown to increase in a dose‐dependent manner the cellular pool of NGF mRNA in murine L‐929 fibroblasts cultured in a serum‐free medium.
212
PHEX analysis in 118 pedigrees reveals new genetic clues in hypophosphatemic rickets
Céline Gaucher,Céline Gaucher,Odile Walrant-Debray,Thy-Minh Nguyen,Laure Esterle,Michèle Garabédian,Frédéric Jehan +6 more
TL;DR: A screening of the different family members should be mandatory when a PHEX mutation is assessed in a sporadic case and the search for another PHex mutation should be systematically proceed when facing a missense mutation.
145
Enhancement of the Synthesis and Secretion of Nerve Growth Factor in Primary Cultures of Glial Cells by Proteases: A Possible Involvement of Thrombin
TL;DR: Newborn rat brain astrocytes cultured in vitro in a chemically defined medium are shown to secrete enhanced levels of nerve growth factor (NGF) when they are exposed to various types of proteases, and γ‐thrombin, which still has some proteolytic activity but has lost its ability to bind to the cell surface, is almost as potent as α‐thROMbin in promoting the release of NGF.
78
Infantile Hypercalcemia and Hypercalciuria: New Insights into a Vitamin D-Dependent Mechanism and Response to Ketoconazole Treatment
Minh Nguyen,Henri Boutignon,Eric Mallet,Agnès Linglart,H. Guillozo,Frédéric Jehan,Michèle Garabédian +6 more
TL;DR: Ketoconazole is a potentially useful and safe agent for treatment of infantile hypercalcemia and abnormal vitamin D metabolism is suggested as the mechanism, possibly involving defective up-regulation of the 24-hydroxylase by 1,25-(OH)2D3, and the klotho-FGF23 axis.
77