Frederic G. Barr
National Institutes of Health
157 Papers
2.1K Citations
Frederic G. Barr is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Rhabdomyosarcoma & Alveolar rhabdomyosarcoma. The author has an hindex of 63, co-authored 149 publications. Previous affiliations of Frederic G. Barr include Children's Hospital of Philadelphia & University of Pennsylvania.
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Papers
Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma.
Naomi Galili,Richard J. Davis,William J. Fredericks,S Mukhopadhyay,F J Rauscher rd,Beverly S. Emanuel,Giovanni Rovera,Frederic G. Barr +7 more
TL;DR: Findings indicate that the t(2;13) generates a potentially tumorigenic fusion transcription factor consisting of intact PAX3 DNA binding domains, a truncated fork head DNA binding domain and C–terminal FKHR regions.
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Negative regulation of the forkhead transcription factor FKHR by Akt.
TL;DR: FKHR may be a direct nuclear regulatory target for Akt in both metabolic and cell survival pathways, and mutation of these three sites to alanine residues enhances the transcriptional activity of FKHR and renders it resistant to inhibition by Akt.
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PAX3-FKHR and PAX7-FKHR Gene Fusions Are Prognostic Indicators in Alveolar Rhabdomyosarcoma: A Report From the Children’s Oncology Group
Poul H. Sorensen,James C. Lynch,Stephen J. Qualman,Roberto Tirabosco,Jerian F. Lim,Harold M. Maurer,Julia A. Bridge,William M. Crist,Timothy J. Triche,Frederic G. Barr +9 more
TL;DR: Not only are PAX-FKHR fusion transcripts specific for ARMS, but expression of PAX3-FK hr and PAX7-FK HR identifies a very high-risk subgroup and a favorable outcome subgroup, respectively, among patients presenting with metastatic ARMS.
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Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors
Jack F. Shern,Li Chen,Juliann Chmielecki,Jun S. Wei,Rajesh Patidar,Mara Rosenberg,Lauren Ambrogio,Daniel Auclair,Jianjun Wang,Young K. Song,Catherine Tolman,Laura Hurd,Hongling Liao,Shile Zhang,Dominik Bogen,Andrew S. Brohl,Sivasish Sindiri,Daniel Catchpoole,Thomas C. Badgett,Gad Getz,Jaume Mora,James R. Anderson,Stephen X. Skapek,Frederic G. Barr,Matthew Meyerson,Matthew Meyerson,Douglas S. Hawkins,Javed Khan +27 more
TL;DR: This is the most comprehensive genomic analysis of rhabdomyosarcoma to date, finding multiple genes were recurrently altered, including NRAS, KRAS, HRAS, FGFR4, PIK3CA, CTNNB1, FBXW7, and BCOR.
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•Journal Article
Fusion of PAX7 to FKHR by the Variant t(1;13)(p36;q14) Translocation in Alveolar Rhabdomyosarcoma
TL;DR: These findings indicate that this t(1;13) rearranges PAX7 on chromosome 1 and fuses it to FKHR on chromosome 13, which results in a chimeric transcript which is similar to the 5' PAX3-3' FK HR transcript formed by the t(2;13), and postulate that these translocations create similar chimeric transcription factors that alter expression of a common group of target genes.
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