Fred Martinson
Northwestern University
7 Papers
44 Citations
Fred Martinson is an academic researcher from Northwestern University. The author has contributed to research in topics: Sertoli cell & Estrogen receptor. The author has an hindex of 7, co-authored 7 publications.
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Papers
A murine model of autosomal dominant neurohypophyseal diabetes insipidus reveals progressive loss of vasopressin-producing neurons
Theron A. Russell,Masafumi Ito,M Ito,Richard N. Yu,Fred Martinson,Jeffrey Weiss,J. Larry Jameson +6 more
TL;DR: This murine model of FNDI recapitulates many features of the human disorder and demonstrates that expression of the mutant AVP precursor leads to progressive neuronal cell loss.
Blockage of the rete testis and efferent ductules by ectopic Sertoli and Leydig cells causes infertility in Dax1-deficient male mice.
TL;DR: Observations reveal abnormal differentiation and proliferation of Leydig cells and Sertoli cells in Dax1-deficient male mice, leading to obstruction of the rete testis and infertility.
Sertoli cell-specific rescue of fertility, but not testicular pathology, in Dax1 (Ahch)-deficient male mice.
Baxter Jeffs,Masafumi Ito,Richard N. Yu,Fred Martinson,Zhen J. Wang,Lynn Doglio,J. Larry Jameson +6 more
TL;DR: Assessment of the effect of Sertoli cell-specific expression of a human DAX1 (AHC) transgene driven using the promoter of the Müllerian inhibiting substance (MIS) gene indicates that Dax1 expression in SERToli cells is adequate to overcome crucial thresholds related to sperm production and function.
Adenovirus-directed expression of dominant negative estrogen receptor induces apoptosis in breast cancer cells and regression of tumors in nude mice.
Eun Jig Lee,Monika Jakacka,W. Rachel Duan,Pei Yu Chien,Fred Martinson,Barry D. Gehm,J. Larry Jameson +6 more
TL;DR: The results indicate that dominant negative ER mutants have the potential to induce apoptosis of T47D cells and regression of tumors, and may provide a useful tool for targeted therapy of ER-positive breast cancer.
Adenovirus-mediated targeted expression of toxic genes to adrenocorticotropin-producing pituitary tumors using the proopiomelanocortin promoter.
TL;DR: It is suggested that the POMC promoter may provide a useful gene therapy strategy for the adjunctive treatment of pituitary tumors causing ACTH-dependent Cushing's syndrome.