Fred Harbinski
Novartis
16 Papers
29 Citations
Fred Harbinski is an academic researcher from Novartis. The author has contributed to research in topics: Genome editing & Transcription factor. The author has an hindex of 7, co-authored 16 publications.
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Papers
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo
William E. Dowdle,Beat Nyfeler,Jane Nagel,Robert Elling,Shanming Liu,Ellen Triantafellow,Suchithra Menon,Zuncai Wang,Ayako Honda,Gwynn Pardee,John Cantwell,Catherine Luu,Ivan Cornella-Taracido,Edmund Harrington,Peter Fekkes,Hong Lei,Qing Fang,Mary Ellen Digan,Debra Burdick,Andrew F. Powers,Stephen B. Helliwell,Simon D’Aquin,Julie Bastien,Henry Wang,Dmitri Wiederschain,Jenny Kuerth,Philip Bergman,David Schwalb,Jason R. Thomas,Savuth Ugwonali,Fred Harbinski,John A. Tallarico,Christine D. Wilson,Vic E. Myer,Jeffery A. Porter,Dirksen E. Bussiere,Peter Finan,Mark Labow,Xiaohong Mao,Lawrence G. Hamann,Brendan D. Manning,Reginald Valdez,Thomas B. Nicholson,Markus Schirle,Mark Knapp,Erin P. Keaney,Leon Murphy +46 more
TL;DR: a4−/− mice exhibit a profound accumulation of iron in splenic macrophages, which are critical for the reutilization of iron from engulfed red blood cells, and a previously unappreciated role for autophagy and NCOA4 in the control of iron homeostasis in vivo is revealed.
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Jenkins-CI, an Open-Source Continuous Integration System, as a Scientific Data and Image-Processing Platform
Ioannis Moutsatsos,Imtiaz Hossain,Claudia Agarinis,Fred Harbinski,Yann Abraham,Luc Dobler,Xian Zhang,Christine D. Wilson,Jeremy L. Jenkins,Nicholas Holway,John A. Tallarico,Christian N. Parker +11 more
TL;DR: This work describes how Jenkins-CI, an “off-the-shelf,” open-source, continuous integration system, is used to build pipelines for processing images and associated data from high-content screening (HCS) and integrated CellProfiler, an open- source image-processing platform, with various HCS utilities and a high-performance Linux cluster.
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Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury
Larraufie Marie-Helene,Xiaolin Gao,Xiaobo Xia,Patrick J. Devine,Joerg Kallen,Dong Liu,Gregory A. Michaud,Andreas Harsch,Savage Nik,Jian Ding,Kian L. Tan,Manuel Mihalic,Silvio Roggo,Stephen M. Canham,Bushell Simon,Philipp Krastel,Jinhai Gao,Aude Izaac,Erhan I. Altinoglu,Philipp Lustenberger,Michael Salcius,Fred Harbinski,Eric T Williams,Liling Zeng,Joseph Loureiro,Feng Cong,Christy Fryer,Lloyd B. Klickstein,John A. Tallarico,Rishi K. Jain,Deborah Rothman,Shaowen Wang +31 more
TL;DR: In this paper, a series of FK506 analogs were identified that act as potent BMP potentiators by sequestering FKBP12 from BMP type I receptors.
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Metabolic Enzyme Sulfotransferase 1A1 Is the Trigger for N-Benzyl Indole Carbinol Tumor Growth Suppression.
Deborah Rothman,Xiaolin Gao,Elizabeth George,Timothy Rasmusson,Diksha Bhatia,Irina Alimov,Louis Wang,Amin Kamel,Panagiotis Hatsis,Yan Feng,Antonin V. Tutter,Gregory A. Michaud,Earl Mcdonald,Kavitha Venkatesan,David Farley,Mary Ellen Digan,Yucheng Ni,Fred Harbinski,Mithat Gunduz,Christine D. Wilson,Alan Buckler,Mark Labow,John A. Tallarico,Vic E. Myer,Jeffrey A. Porter,Shaowen Wang +25 more
TL;DR: This study demonstrates that the selectivity profile for N-BICs is through conversion by SULT1A1 from an inactive prodrug to an active species that induces cell death and tumor suppression.
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Comparative Studies Reveal Robust HbF Induction By Editing of HBG1/2 Promoters or BCL11A Erythroid-Enhancer in Human CD34+ Cells but That BCL11A Erythroid-Enhancer Editing Is Associated with Selective Reduction in Erythroid Lineage Reconstitution in a Xenotransplantation Model
Kai-Hsin Chang,Minerva E. Sanchez,Jack Heath,Edouard deDreuzy,Scott Haskett,Abigail Vogelaar,Kiran Gogi,Jen Da Silva,Tongyao Wang,Andrew Sadowski,Gregory Gotta,Jamaica Siwak,Ramya Viswanathan,Katherine Loveluck,Hoson Chao,Eric L. Tillotson,Aditi Chalishazar,Abhishek Dass,Frederick Ta,Emily Brennan,Diana Tabbaa,Eugenio Marco,John A. Zuris,Deepak Reyon,Meltem Isik,Ari E. Friedland,Terence Ta,Fred Harbinski,Georgia Giannoukos,Sandra Teixeira,Chris Wilson,Charlie Albright,Haiyan Jiang +32 more
TL;DR: Ex vivo erythroid cultures suggests BCL11A erystroid-enhancer editing may lead to slightly increased apoptosis during eryhroid differentiation, and reduced editing levels at BCL 11A ERYthroid-specific enhancer in the erytroid compartment compared to unfractionated bone marrow (BM) or other human lineages.
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