Frauke Meyer
German Cancer Research Center
7 Papers
Frauke Meyer is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Biology & Cancer research. The author has an hindex of 1, co-authored 1 publications.
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Papers
Aberrant ERBB4-SRC Signaling as a Hallmark of Group 4 Medulloblastoma Revealed by Integrative Phosphoproteomic Profiling.
Antoine Forget,Antoine Forget,Loredana Martignetti,Stéphanie Puget,Laurence Calzone,Sebastian Brabetz,Daniel Picard,Arnau Montagud,Stéphane Liva,Alexandre Sta,Florent Dingli,Guillaume Arras,Jaime Rivera,Damarys Loew,Aurore Besnard,Joelle Lacombe,Mélanie Pagès,Pascale Varlet,Christelle Dufour,Hua Yu,Hua Yu,Audrey Mercier,Audrey Mercier,Emilie Indersie,Emilie Indersie,Anaïs Chivet,Anaïs Chivet,Sophie Leboucher,Sophie Leboucher,Laura Sieber,Kevin Beccaria,Michael Gombert,Frauke Meyer,Nan Qin,Jasmin Bartl,Lukas Chavez,Konstantin Okonechnikov,Tanvi Sharma,Venu Thatikonda,Franck Bourdeaut,Celio Pouponnot,Celio Pouponnot,Vijay Ramaswamy,Andrey Korshunov,Arndt Borkhardt,Guido Reifenberger,Patrick Poullet,Michael D. Taylor,Marcel Kool,Stefan M. Pfister,Stefan M. Pfister,Daisuke Kawauchi,Emmanuel Barillot,Marc Remke,Olivier Ayrault,Olivier Ayrault +55 more
TL;DR: Proteomic and phosphoproteomic analyses identify aberrant ERBB4-SRC signaling in group 4 and unveils an oncogenic pathway and potential therapeutic vulnerability in the most common medulloblastoma subgroup.
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Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti-CD47-induced macrophage phagocytosis via NF-kB-TGM2 driven tumor inflammation
Viktoria Marquardt,Johanna Theruvath,David Pauck,Daniel Picard,Nan Qin,Lena Blümel,Mara Maue,Jasmin Bartl,Ulvi Ahmadov,Maike Langini,Frauke Meyer,Allison Cole,José Ignacio de la Cruz-Cruz,Claus Moritz Graef,Matthias Wölfl,Till Milde,Olaf Witt,Anat Erdreich-Epstein,Gabriel Leprivier,Ulf Dietrich Kahlert,Anja Stefanski,Kai Stühler,Stephen T. Keir,Darell D. Bigner,Julia Hauer,Thomas Beez,Christiane B. Knobbe-Thomsen,Ute Fischer,Jörg Felsberg,Finn K. Hansen,Rajeev Vibhakar,Sujatha Venkatraman,Samuel H. Cheshier,Guido Reifenberger,Arndt Borkhardt,Thomas Kurz,Marc Remke,Siddhartha Mitra +37 more
TL;DR: In this article , a cross-entity, epigenetic drug screen was performed to evaluate therapeutic vulnerabilities in myC-driven medulloblastoma (Grp3-MB), which sensitizes them to macrophage-mediated phagocytosis by targeting the CD47signal regulatory protein α (SIRPα) innate checkpoint pathway.
Primary cilia contribute to the aggressiveness of atypical teratoid/rhabdoid tumors
Lena Blümel,Nan Qin,Johannes Berlandi,Eunice Paisana,Rita Cascão,Carlos Custódia,David Pauck,Daniel Picard,Maike Langini,Kai Stühler,Frauke Meyer,Sarah Göbbels,Bastian Malzkorn,Max C. Liebau,João T. Barata,Astrid Jeibmann,Kornelius Kerl,Serap Erkek,Marcel Kool,Stefan M. Pfister,Pascal Johann,Michael C. Frühwald,Arndt Borkhardt,Guido Reifenberger,Claudia C. Faria,Ute Fischer,Martin Hasselblatt,Jasmin Bartl,Marc Remke +28 more
TL;DR: In this article , the authors show that primary cilia are present across all AT/RT subgroups with specific enrichment in AT/Rhabdoid tumor patient samples, and demonstrate that the primary ciliogenesis contributes to the biology of AT/T.
Integrative multi-omics reveals two biologically distinct groups of pilocytic astrocytoma
Daniel Picard,Jörg Felsberg,Maike Langini,Pawel Stachura,Nan Qin,Jadranka Macas,Yvonne Reiss,Jasmin Bartl,Florian Selt,Romain Sigaud,Frauke Meyer,Anja Stefanski,Kai Stühler,Lúcia Roque,R. Roque,Aleksandra A. Pandyra,Triantafyllia Brozou,Christiane B. Knobbe-Thomsen,Karl H. Plate,Alexander Roesch,Till Milde,Guido Reifenberger,Gabriel Leprivier,Claudia C. Faria,Marc Remke +24 more
TL;DR: Integrative multi-omics of PA identified biologically distinct and prognostically relevant tumor groups that may improve risk stratification of this single pathway driven tumor type.
2
Intratumoral heterogeneity of MYC drives medulloblastoma metastasis and angiogenesis.
Nan Qin,Eunice Paisana,Maike Langini,Daniel Picard,Bastian Malzkorn,Carlos Custódia,Rita Cascão,Frauke Meyer,Lena Blümel,Sarah Göbbels,Kübra Taban,Jasmin Bartl,Nicole Bechmann,Catleen Conrad,Jan Gravemeyer,Jürgen C. Becker,Anja Stefanski,Stéphanie Puget,João T. Barata,Kai Stühler,Ute Fischer,Jörg Felsberg,Olivier Ayrault,Guido Reifenberger,Arndt Borkhardt,Graeme Eisenhofer,Claudia C. Faria,Marc Remke +27 more
TL;DR: This study reveals the functional relevance of clonal diversity and highlights the therapeutic potential of targeting the secretome to interrupt interclonal communication and progression in high-risk medulloblastoma.