Fraser McBlane
European Institute of Oncology
11 Papers
243 Citations
Fraser McBlane is an academic researcher from European Institute of Oncology. The author has contributed to research in topics: Recombination signal sequences & Histone. The author has an hindex of 9, co-authored 9 publications. Previous affiliations of Fraser McBlane include Basel Institute for Immunology.
Chat about Author
Papers
Stimulation of V(D)J recombination by histone acetylation
Fraser McBlane,Joan Boyes +1 more
TL;DR: A role for histone acetylation in stimulating recombination in vivo through disruption of higher-order chromatin structures is suggested, as well as a role for nucleosome-mediated repression of RSS recognition and cleavage in vitro.
125
Recombinase, chromosomal translocations and lymphoid neoplasia: targeting mistakes and repair failures.
Rodrig Marculescu,Katrina Vanura,Bertrand Montpellier,Sandrine Roulland,Trang Le,Jean-Marc Navarro,Ulrich Jäger,Fraser McBlane,Bertrand Nadel +8 more
TL;DR: Surprisingly, V(D)J-mediated translocations turn out to be restricted to two specific sub-types of lymphoid malignancies, T-cell acute lymphoblastic leukemias, and a restricted set of mature B-cell Non-Hodgkin's lymphomas.
107
Regulation of V(D)J recombination by nucleosome positioning at recombination signal sequences
TL;DR: It is suggested that nucleosome positioning by RSSs provides a previously unanticipated level of protection and regulation of V(D)J recombination.
Immunogenicity assessment of AAV-based gene therapies: An IQ consortium industry white paper
Tong-Yuan Yang,Manuela Braun,Wibke Lembke,Fraser McBlane,John Kamerud,Stephen DeWall,Edit Tarcsa,Xiao-Fen Fang,Lena Hofer,Uma Kavita,Vijay V. Upreti,Swati Gupta,Lina Loo,Alison J. Johnson,Rakesh K. Chandode,Kay Stubenrauch,Maya Vinzing,Cindy Q. Xia,Vibha Jawa +18 more
TL;DR: In this paper , the authors present bioanalytical strategies, methodologies, and assay validation applied to appropriately monitor immunogenicity in AAV gene therapy-treated subjects, and summarize the risks and their impact in nonclinical and clinical studies, and various clinical mitigation strategies.
68
V(D)J Recombinase-Mediated Processing of Coding Junctions at Cryptic Recombination Signal Sequences in Peripheral T Cells during Human Development
Janet M. Murray,J. Patrick O'Neill,Terri L. Messier,Jami Rivers,Vernon E. Walker,Brien McGonagle,Lucy Trombley,Lindsay G. Cowell,Garnett Kelsoe,Fraser McBlane,Barry A. Finette +10 more
TL;DR: Insight is gained into the mechanisms mediating these developmentally specific V(D)J recombinase-mediated rearrangements in humans by investigating coding junctions associated with cRSS sites at the hypoxanthine-guanine phosphoribosyltransferase (HPRT) locus in peripheral T cells from 111 children.
18