Fraser J. Moss
Case Western Reserve University
38 Papers
156 Citations
Fraser J. Moss is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Protein subunit & Chemistry. The author has an hindex of 12, co-authored 24 publications. Previous affiliations of Fraser J. Moss include University College London & California Institute of Technology.
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Papers
The ducky mutation in Cacna2d2 results in altered Purkinje cell morphology and is associated with the expression of a truncated alpha 2 delta-2 protein with abnormal function.
Jens Brodbeck,Anthony Davies,Jo-Maree Courtney,Alon Meir,Nuria Balaguero,C Canti,Fraser J. Moss,Karen M. Page,Wendy S. Pratt,Steven P. Hunt,Jane Barclay,M Rees,Annette C. Dolphin +12 more
TL;DR: The mouse mutant ducky, a model for absence epilepsy, is characterized by spike-wave seizures and cerebellar ataxia, and co-expression with the truncated mutant α2δ-2 protein reduced current density, indicating that it may contribute to the du phenotype.
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The novel product of a five-exon stargazin-related gene abolishes CaV2.2 calcium channel expression
Fraser J. Moss,Patricia Viard,Anthony Davies,Federica Bertaso,Karen M. Page,Alex Graham,C Canti,Mary Plumpton,Christopher Plumpton,Jeffrey J. Clare,Annette C. Dolphin +10 more
TL;DR: Cloned and characterized a new member of the voltage‐dependent Ca2+ channel γ subunit family, with a novel gene structure and striking properties, which imply that it represents a distinct subdivision of the family of proteins identified by their structural and sequence homology to stargazin.
Human neuronal stargazin-like proteins, γ2, γ3 and γ4; an investigation of their specific localization in human brain and their influence on CaV2.1 voltage-dependent calcium channels expressed in Xenopus oocytes.
TL;DR: The fact that neither γ2 nor γ4 modulated the properties of a VD CC complex with which they could associate in vivo in Purkinje cells adds weight to the hypothesis that the principal role of these proteins is not as auxiliary subunits of VDCCs.
The stargazin-related protein gamma 7 interacts with the mRNA-binding protein heterogeneous nuclear ribonucleoprotein A2 and regulates the stability of specific mRNAs, including CaV2.2.
Laurent Ferron,Anthony Davies,Karen M. Page,David J. Cox,Jérôme Leroy,Dominic Waithe,Adrian J. Butcher,Priya Sellaturay,Steven Bolsover,Wendy S. Pratt,Fraser J. Moss,Annette C. Dolphin +11 more
TL;DR: The results indicate that γ7 plays a role in stabilizing CaV2.2 mRNA, and it is shown that it binds directly via its C terminus to a heterogeneous nuclear ribonucleoprotein (hnRNP A2), which also binds to a motif in CaV 2.2 RNA.
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Carbon dioxide transport across membranes.
Marie Michenkova,Sara Taki,Matthew C. Blosser,Hyea J. Hwang,Thomas Kowatz,Fraser J. Moss,Rossana Occhipinti,Xue Qin,Soumyo Sen,Eric Shinn,Deng-Ke Wang,Brian Zeise,Pan Zhao,Noah Malmstadt,Ardeschir Vahedi-Faridi,Emad Tajkhorshid,Walter F. Boron +16 more
TL;DR: Carbon dioxide (CO2) movement across cellular membranes is passive and governed by Fick's law of diffusion as mentioned in this paper, until recently, we believed that gases cross biological membranes exclusively by dissolv...
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