Frank Simonis
13 Papers
55 Citations
Frank Simonis is an academic researcher. The author has contributed to research in topics: Peritoneal dialysis & Artificial kidney. The author has an hindex of 3, co-authored 13 publications.
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Papers
A regenerable potassium and phosphate sorbent system to enhance dialysis efficacy and device portability: an in vitro study
Maarten Wester,Frank Simonis,Karin G.F. Gerritsen,Walther H. Boer,Will K. W. H. Wodzig,Jeroen P. Kooman,Jaap A. Joles +6 more
TL;DR: Res-A and FeOOH are suitable, regenerizable sorbents for potassium and phosphate removal in dialysate regeneration and use of zirconium carbonate and ZIR-hydr may further increase phosphate adsorption, but may compromise sorbent regenerability.
Removal of urea by electro-oxidation in a miniature dialysis device: a study in awake goats
Maarten Wester,Maaike K. van Gelder,Jaap A. Joles,Frank Simonis,Diënty H M Hazenbrink,Theo W. M. van Berkel,Koen R D Vaessen,Walther H. Boer,Marianne C. Verhaar,Karin G.F. Gerritsen +9 more
TL;DR: Clinical relevant urea removal was achieved in vivo by electro-oxidation in goats and effectiveness and safety testing in a large-animal model with uremia is now indicated.
Evaluation of a system for sorbent-assisted peritoneal dialysis in a uremic pig model.
Maaike K. van Gelder,Joost C de Vries,Frank Simonis,Anneke S Monninkhof,Diënty H M Hazenbrink,Giulia Ligabue,Silvia Giovanella,Jaap A. Joles,Marianne C. Verhaar,Maria Auxiliadora Bajo Rubio,Rafael Selgas,Gianni Cappelli,Karin G.F. Gerritsen +12 more
TL;DR: Sorbent‐assisted peritoneal dialysis treatment in a uremic pig model is safe and enhances small solute clearance as compared to a static dwell and future studies in humans or animal species with higher peritoneAL transport should elucidate whether the SAPD system enhances clearance to a clinically relevant extent asCompared to conventional PD.
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Safety of electrooxidation for urea removal in a wearable artificial kidney is compromised by formation of glucose degradation products
Maaike K. van Gelder,Jeroen C. Vollenbroek,Babette H Lentferink,Diënty H M Hazenbrink,Paul J. Besseling,Frank Simonis,Silvia Giovanella,Giulia Ligabue,Maria Auxiliadora Bajo Rubio,Gianni Cappelli,Jaap A. Joles,Marianne C. Verhaar,Karin G.F. Gerritsen +12 more
TL;DR: In this article, the authors present results on glucose degradation products (GDPs) formed during electrooxidation (EO), a technique that applies a current to the dialysate to convert urea into nitrogen, carbon dioxide and hydrogen gas.
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A regenerable potassium and phosphate sorbent system to enhance dialysis efficacy and device portability: a study in awake goats.
Maarten Wester,Karin G.F. Gerritsen,Frank Simonis,Walther H. Boer,Diënty H M Hazenbrink,Koen R D Vaessen,Marianne C. Verhaar,Jaap A. Joles +7 more
TL;DR: Clinical relevant, concentration-dependent, pH-neutral potassium and phosphate removal in vivo with small volumes of regenerable ion exchangers in a wearable dialysis device appears to be effective with a low-risk profile.