Frank Roossink
University Medical Center Groningen
7 Papers
30 Citations
Frank Roossink is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Cervical cancer & Cancer. The author has an hindex of 4, co-authored 7 publications.
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Papers
Prognostic cell biological markers in cervical cancer patients primarily treated with (chemo)radiation: a systematic review.
Maartje G. Noordhuis,Jasper J. H. Eijsink,Frank Roossink,Pauline de Graeff,Elisabeth Pras,Ed Schuuring,G. Bea A. Wisman,Geertruida H. de Bock,Ate G.J. van der Zee +8 more
TL;DR: Targeting pathways involved in angiogenesis and hypoxia, COX-2, and serum SCC-ag levels are associated with a poor prognosis, whereas targeting these pathways in combination with chemoradiation may improve survival in advanced-stage cervical cancer patients.
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DNA hypermethylation biomarkers to predict response to cisplatin treatment, radiotherapy or chemoradiation: the present state of art
TL;DR: This review summarized the present state of art regarding hypermethylated genes and their affected signaling pathways that are associated with outcome after cisplatin treatment, radiotherapy or chemoradiation in cervical cancer and concluded that a comprehensive screening of a large panel of methylation markers associated with both good as well as poor clinical outcome have to be investigated.
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Construction of a triple modified p53 containing DNA vaccine to enhance processing and presentation of the p53 antigen
TL;DR: Preliminary testing in normal and HLA-A2 mice of this triple modified p53 containing DNA construct meant for human application showed a trend towards a superior immunogenicity.
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Abstract 3463: The role of Atg13 in response to radiotherapy in cervical cancer cells
TL;DR: In-vitro results indicate that the autophagic ULK1 pathway plays an important role in protecting cervical cancer cells to irradiation and inhibition of autophagy may be an interesting strategy to sensitize cervical adenocarcinoma to radiotherapy.
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Abstract 4171: The role of ATM and 53BP1 as predictive markers and therapeutic targets in advanced stage cervical cancer
Frank Roossink,Hylke W. Wieringa,Maartje G. Noordhuis,Mirjam Kok,Klaske A. ten Hoor,Geertruida H. de Bock,Steven de Jong,Ate G.J. van der Zee,Ed Schuuring,G. Bea A. Wisman,Marcel A. T. M. van Vugt +10 more
TL;DR: The data suggest the prognostic value of ATM signaling for responses to chemoradiation and point at ATM inhibition as a potential therapeutic target to increase treatment efficacy in advanced stage cervical cancers.
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