Frank Peddie
University of South Australia
9 Papers
95 Citations
Frank Peddie is an academic researcher from University of South Australia. The author has contributed to research in topics: Buccal administration & Etching (microfabrication). The author has an hindex of 6, co-authored 9 publications.
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Papers
Dry hybrid lipid-silica microcapsules engineered from submicron lipid droplets and nanoparticles as a novel delivery system for poorly soluble drugs.
Spomenka Simovic,Peter J Heard,He Hui,Yunmei Song,Frank Peddie,Andrew K. Davey,AC Lewis,Thomas Rades,Clive A. Prestidge +8 more
TL;DR: The hybrid lipid-silica microcapsules improve oral absorption by enhancing lipolysis and drug dissolution and showed the highest maximum plasma concentration (C(max)) among the investigated formulations.
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Particle size reduction to the nanometer range: a promising approach to improve buccal absorption of poorly water-soluble drugs.
TL;DR: The design of the buccal patch allows for drug incorporation without the need to change the mucoadhesive component, and is potentially suited to a range of poorly water-soluble compounds.
Peptide and protein loading into porous silicon wafers
Clive A. Prestidge,Timothy J. Barnes,Agnieszka Mierczynska-Vasilev,Ivan M. Kempson,Frank Peddie,Christian Barnett +5 more
TL;DR: In this paper, the influence of peptide/protein size and hydrophobicity on the physical and chemical aspects of loading within porous silicon (pSi) wafer samples has been determined using Atomic Force Microscopy (AFM) and Time-of-Flight Secondary Ion Mass Spectroscopy (ToF-SIMS).
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Loading and release of a model protein from porous silicon powders
Clive A. Prestidge,Timothy J. Barnes,Agnieszka Mierczynska-Vasilev,William Skinner,Frank Peddie,Christian Barnett +5 more
TL;DR: In this article, the loading of a hydrophilic protein, Papain into anodised and stain etched p-Si powders has been investigated using X-ray photoelectron spectroscopy (XPS) and infrared spectrograms (FTIR) and correlations made with the release kinetics.
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A novel tri-layered buccal mucoadhesive patch for drug delivery: assessment of nicotine delivery.
TL;DR: This study assesses the potential of a novel delivery device for administering drugs that suffer from a high degree of first‐pass metabolism.
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