Frank Park
Medical College of Wisconsin
59 Papers
281 Citations
Frank Park is an academic researcher from Medical College of Wisconsin. The author has contributed to research in topics: Kidney & Biology. The author has an hindex of 28, co-authored 52 publications. Previous affiliations of Frank Park include LSU Health Sciences Center New Orleans & Louisiana State University.
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Papers
Quantification of nitric oxide synthase activity in microdissected segments of the rat kidney.
TL;DR: It is demonstrated that the greatest enzymatic activity for NO production in the kidney is in the IMCD, three- to sixfold less activity is present in the Glm and VR, and minimal NOS activity is found in other segments studied.
191
Lentiviral vectors: are they the future of animal transgenesis?
TL;DR: The advantages and disadvantages of lentiviral transgenesis vs. other approaches to produce transgenic animals will be compared with regard to efficiency, the ability to promote persistent transgene expression, and the time necessary to generate a sufficient number of animals for phenotyping.
179
Therapeutic levels of human factor VIII and IX using HIV-1-based lentiviral vectors in mouse liver.
TL;DR: It is demonstrated that lentiviral vectors can produce therapeutic levels of coagulation factors in vivo, which can be enhanced with hepatocellular proliferation, and humoral immunity-limited gene expression in immunocompetent mice.
178
Direct injection into the dorsal root ganglion: technical, behavioral, and histological observations
Gregory Fischer,Sandra Kostic,Hiroyuki Nakai,Frank Park,Damir Sapunar,Hongwei Yu,Quinn H. Hogan,Quinn H. Hogan +7 more
TL;DR: It is found that 2 μl of dye injected through a pulled glass pipette directly into the distal DRG, exposed by a minimal foraminotomy, produces complete filling of the DRG with limited extension into the spinal roots.
107
The Intermediate Conductance Calcium-activated Potassium Channel KCa3.1 Regulates Vascular Smooth Muscle Cell Proliferation via Controlling Calcium-dependent Signaling
Dan Bi,Kazuyoshi Toyama,Vincent Lemaître,Jun Takai,Fan Fan,David Paul Jenkins,Heike Wulff,David D. Gutterman,Frank Park,Hiroto Miura,Hiroto Miura +10 more
TL;DR: KCa3.1 plays an important role in VSMC proliferation via controlling Ca2+-dependent signaling pathways, and its modulation may therefore constitute a new therapeutic target for cell proliferative diseases such as atherosclerosis.
93