Frank Bröcker
University of Duisburg-Essen
6 Papers
39 Citations
Frank Bröcker is an academic researcher from University of Duisburg-Essen. The author has contributed to research in topics: Yeast artificial chromosome & Locus (genetics). The author has an hindex of 6, co-authored 6 publications.
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Papers
Minimal deletion of 3p13-->14.2 associated with immortalization of human uroepithelial cells.
Lydia Vieten,Cassandra D. Belair,Lena Savelieva,Knut Jülicher,Frank Bröcker,Walter Bardenheuer,Jochen Schütte,Bertram Opalka,Catherine A. Reznikoff +8 more
TL;DR: The results suggest the presence in this region of genes involved in the control of senescence in vitro and possibly tumorigenesis in vivo, and the smallest common overlap of 3p deletions in HPV16 E6‐ or E7‐immortalized HUCs.
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Novel Tumor Suppressor Locus in Human Chromosome Region 3p14.2
Knut Jülicher,Guido Marquitan,Nicola Werner,Walter Bardenheuer,Lydia Vieten,Frank Bröcker,Hüsnü Topal,Siegfried Seeber,Bertram Opalka,Jochen Schütte +9 more
TL;DR: These data provide strong evidence for the existence of a novel tumor suppressionor locus adjacent to the previously identified candidate tumor suppressor gene, FHIT, in 3p14.2.
Assignment of human filamin gene FLNB to human chromosome band 3p14.3 and identification of YACs containing the complete FLNB transcribed region.
Frank Bröcker,W Bardenheuer,Lydia Vieten,K Jülicher,N Werner,G Marquitan,D. Michael,Bertram Opalka,Jochen Schütte +8 more
TL;DR: Results show that the FLNB coding region maps to chromosome region 3p14.3 by fluorescence in situ hybridization with YACs from a previously established3p14–specific YAC contig.
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Yeast artificial chromosome transfer into human renal carcinoma cells by spheroplast fusion.
TL;DR: Evaluation of YAC transfer strategies into a human renal cell carcinoma cell line by yeast spheroplast fusion and cationic lipids demonstrates that under certain experimental conditions efficient Yac transfer into human cells by sphero Plast fusion is possible and may be useful for the cloning of human disease-related genes.
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Identification of novel 'expressed sequence tags' within the FHIT gene locus in human chromosome region 3p14.2
Andreas Lux,Walter Bardenheuer,Dagmar Michael,Frank Bröcker,Knut Jülicher,Lydia Vieten,Susanne C. Michaelis,Siegfried Seeber,Bertram Opalka,Judith Schütte +9 more
TL;DR: This work reports on the identification of five novel ‘expressed sequence tags’ (ESTs) within 3p14.2 which map proximal to exon 9 of the candidate TSG, FHIT, and may be valuable for elucidation of the supposed TSG content in 3p 14.2.
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