François Cesbron
Heidelberg University
5 Papers
François Cesbron is an academic researcher from Heidelberg University. The author has contributed to research in topics: Circadian clock & Promoter. The author has an hindex of 5, co-authored 5 publications.
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Papers
Genome-wide and phase-specific DNA-binding rhythms of BMAL1 control circadian output functions in mouse liver.
Guillaume Rey,François Cesbron,Jacques Rougemont,Jacques Rougemont,Hans Reinke,Hans Reinke,Hans Reinke,Michael Brunner,Felix Naef,Felix Naef +9 more
TL;DR: Temporal mapping during a circadian day of binding sites for the BMAL1 transcription factor in mouse liver reveals genome-wide daily rhythms in DNA binding and uncovers output functions that are controlled by the circadian oscillator.
Frequency Modulation of Transcriptional Bursting Enables Sensitive and Rapid Gene Regulation.
TL;DR: It is shown that quantitating the temporal regulation of key gene states (transcriptionally inactive, active, and refractory) provides a parsimonious framework for analyzing gene regulation and demonstrates the relevance of a kinetic, non-equilibrium framework for understanding transcriptional regulation.
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Transcriptional refractoriness is dependent on core promoter architecture.
TL;DR: The results suggest that refractory promoters carry a physical memory of their recent transcription history and genome-wide analysis of light-induced transcription suggests that refractoriness is rather widespread and a property of promoter architecture.
Light-dependent and circadian transcription dynamics in vivo recorded with a destabilized luciferase reporter in Neurospora.
TL;DR: A short-lived luciferase is created by fusing a PEST signal to its C-terminus and the LUC-PEST reporter system is applied to record in vivo transcription dynamics associated with the Neurospora circadian clock and its blue-light photosensory system over the course of several days.
Dawn- and dusk-phased circadian transcription rhythms coordinate anabolic and catabolic functions in Neurospora
TL;DR: A substantial plasticity of the circadian transcriptome is suggested with respect to the number of rhythmic genes as well as amplitude and phase of the expression rhythms and a major role is emphasized in the temporal organization of metabolism and physiology of Neurospora.