Franck E. Nicolini
University of Lyon
15 Papers
29 Citations
Franck E. Nicolini is an academic researcher from University of Lyon. The author has contributed to research in topics: Medicine & CD34. The author has an hindex of 6, co-authored 15 publications.
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Papers
Primitive CML cell expansion relies on abnormal levels of BMPs provided by the niche and on BMPRIb overexpression.
Bastien Laperrousaz,Sandrine Jeanpierre,Karen Sagorny,Thibault Voeltzel,Sophie Ramas,Bastien Kaniewski,Martine Ffrench,Stéphanie Salesse,Franck E. Nicolini,Véronique Maguer-Satta +9 more
TL;DR: It is demonstrated that deregulation of intracellular BMP signaling in primary CP-CML samples corrupts and amplifies their response to exogenous BMP2 and BMP4, which are abnormally abundant within the tumor microenvironment.
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Oncogene- and drug resistance-associated alternative exon usage in acute myeloid leukemia (AML).
Aminetou Mint Mohamed,Marie Balsat,Morgan Thenoz,Catherine Koering,Lea Payen-Gay,Meyling Cheok,Hussein Mortada,Didier Auboeuf,Christiane Pinatel,Mohamed El-Hamri,Charles Dumontet,Emeline Cros,Pascale Flandrin-Gresta,Olivier Nibourel,Claude Preudhomme,Mauricette Michallet,Xavier Thomas,Franck E. Nicolini,Françoise Solly,Denis Guyotat,Lydia Campos,Eric Wattel,Franck Mortreux +22 more
TL;DR: Exon-array analysis and exon-specific PCR identified new putative pathways that could help increase the understanding of the effects mediated by DEK or WT1, which may allow the targeting of these pathways to prevent resistance of AML cells to chemotherapeutic agents.
Phase II prospective study of treosulfan-based reduced-intensity conditioning in allogeneic HSCT for hematological malignancies from 10/10 HLA-identical unrelated donor
Mauricette Michallet,Mohamad Sobh,Noel Milpied,Jacques-Olivier Bay,Sabine Furst,Jean-Luc Harousseau,Mohamad Mohty,Franck E. Nicolini,Hélène Labussière,Nathalie Tedone,Stephane Morisset,Stephane Vigouroux,Joachim Baumgart,Reza Tabrizi,Didier Blaise +14 more
TL;DR: Treosulfan appears to be a good alternative for conditioning of MUD transplant patients with promising results in terms of OS, relapse, and TRM.
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Chromatin redistribution of the DEK oncoprotein represses hTERT transcription in leukemias.
Maroun Karam,Morgan Thenoz,Valérie Capraro,Jean-Philippe Robin,Christiane Pinatel,Agnès Lançon,Perrine Galia,David Sibon,David Sibon,Xavier Thomas,Sophie Ducastelle-Lepretre,Franck E. Nicolini,Mohamed Elhamri,Youcef Chelghoun,Eric Wattel,Franck Mortreux +15 more
TL;DR: Dek emerges as an hTERT repressor shared by various leukemia subtypes and seems involved in the deregulation of numerous genes associated with leukemogenesis, including those of cancer-prone genes.
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A minimal rupture cascade model for living cell plasticity
Stefano Polizzi,Stefano Polizzi,Bastien Laperrousaz,Francisco J. Pérez-Reche,Franck E. Nicolini,Véronique Maguer Satta,Véronique Maguer Satta,Alain Arneodo,Françoise Argoul +8 more
TL;DR: This study was supported by the Joliot Curie and Physics Laboratories (ENS Lyon/CNRS), the Agence Nationale de la Recherche ANR-10-BLAN-1516, INSERM, Novartis, Ligue Nationale contre le Cancer (Saone et Loire) and Cent pour Cent la Vie.
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