Franck Broly
university of lille
92 Papers
980 Citations
Franck Broly is an academic researcher from university of lille. The author has contributed to research in topics: Gene & Genotype. The author has an hindex of 33, co-authored 89 publications. Previous affiliations of Franck Broly include Lille University of Science and Technology & Calmette Hospital.
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Papers
Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy
Jean-Frederic Colombel,Nicolas Ferrari,Hervé Debuysere,Philippe Marteau,Jean Pierre Gendre,Bruno Bonaz,Soulé Jc,Robert Modigliani,Yvan Touze,Pascale Catala,Christian Libersa,Franck Broly +11 more
TL;DR: Twenty-seven percent of patients with CD and myelosuppression during azathioprine therapy had mutant alleles of the TPMT gene associated with enzyme deficiency, which is more often caused by other factors than other factors.
632
Nomenclature for human CYP2D6 alleles.
Ann K. Daly,Jürgen Brockmöller,Franck Broly,Michel Eichelbaum,William E. Evans,Frank J. Gonzalez,J D Huang,Jeffrey R. Idle,Magnus Ingelman-Sundberg,Takashi Ishizaki,Evelyne Jacqz-Aigrain,Urs A. Meyer,Daniel W. Nebert,Vidar M. Steen,C R Wolf,Ulrich M. Zanger +15 more
TL;DR: It is proposed that alleles be designated by CYP2D6 followed by an asterisk and a combination of roman letters and arabic numerals distinct for each allele with the number specifying the key mutation and, where appropriate, a letter specifying additional mutations.
421
Candida albicans Colonization and ASCA in Familial Crohn's Disease
Annie Standaert-Vitse,Boualem Sendid,Marie Joossens,Nadine François,Peggy Vandewalle-El Khoury,Julien Branche,Herbert J. Van Kruiningen,Thierry Jouault,Paul Rutgeerts,Corinne Gower-Rousseau,Christian Libersa,Christel Neut,Franck Broly,Mathias Chamaillard,Severine Vermeire,Daniel Poulain,Jean-Frederic Colombel +16 more
TL;DR: CD patients and their first-degree HRs are more frequently and more heavily colonized by C. albicans than are controls and ASCAs correlate with C.Albicans colonization in HRs but not in CD.
199
Genotypic and phenotypic analysis of the polymorphic thiopurine S‐methyltransferase gene (TPMT) in a European population
Catherine Spire Vayron De La Moureyre,Hervé Debuysere,Bruno Mastain,Elizabeth Vinner,D. Marez,Jean-Marc Lo Guidice,Dany Chevalier,Serge A. Brique,Kokou B. Motte,Jean-Frederic Colombel,Dominique Turck,Christian Noel,René-Marc Flipo,Annie Pol,Michel Lhermitte,Jean-Jacques Lafitte,Christian Libersa,Franck Broly +17 more
TL;DR: A clear negative correlation between the total number of repeats from both alleles and the T PMT activity level was observed, indicating that VNTRs contribute to interindividual variations of TPMT activity.
188
Cytochrome P450 2D6 genotype and methadone steady-state concentrations
Chin B. Eap,Franck Broly,Annie Mino,Robert Hämmig,Jean J. Deglon,Claude Uehlinger,Daniel Meili,AF Chevalley,Gilles Bertschy,Daniele Fabio Zullino,Markus Kosel,Martin Preisig,Pierre Baumann +12 more
TL;DR: Results confirm the involvement of cytochrome P450 2D6 in methadone metabolism and the influence of the ultrarapid metabolizer status on the outcome of the MMT.
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