Francisca Beato
University of South Florida
18 Papers
53 Citations
Francisca Beato is an academic researcher from University of South Florida. The author has contributed to research in topics: Transplantation & Hematopoietic stem cell transplantation. The author has an hindex of 8, co-authored 18 publications.
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Papers
Ex vivo expansion of human Tregs specific for alloantigens presented directly or indirectly
TL;DR: A platform for the selective expansion of Tregs against major and possibly minor histocompatibility antigens is provided and the feasibility of adoptive immunotherapy trials using T Regs with indirect allo-recognition for preventing GVHD while sparing GVL effects is predicted.
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Dual Farnesyl and Geranylgeranyl Transferase Inhibitor Thwarts Mutant KRAS-Driven Patient-Derived Pancreatic Tumors
Aslamuzzaman Kazi,Shengyan Xiang,Hua Yang,Liwei Chen,Perry Kennedy,Muhammad Ayaz,Steven Fletcher,Christopher G. Cummings,Harshani R. Lawrence,Francisca Beato,Ya'an Kang,Michael P. Kim,Andrea E. Delitto,Patrick W. Underwood,Jason B. Fleming,Jose G. Trevino,Andrew D. Hamilton,Saïd M. Sebti,Saïd M. Sebti +18 more
TL;DR: The development of this novel dual FGTI overcomes a major hurdle in KRAS resistance, thwarting growth of patient-derived mutant KRAS–driven xenografts from patients with pancreatic cancer, and as such it warrants further preclinical and clinical studies.
CD4+ T cell STAT3 phosphorylation precedes acute GVHD, and subsequent Th17 tissue invasion correlates with GVHD severity and therapeutic response.
Brian C. Betts,Elizabeth M. Sagatys,Anandharaman Veerapathran,Mark C. Lloyd,Francisca Beato,Harshani R. Lawrence,Binglin Yue,Jongphil Kim,Said M. Sebti,Claudio Anasetti,Joseph Pidala +10 more
TL;DR: It is concluded that STAT3 signaling and resultant Th17 tissue accumulation are closely associated with acute GVHD onset, severity, and treatment outcome.
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Establishing a living biobank of patient-derived organoids of intraductal papillary mucinous neoplasms of the pancreas
Francisca Beato,Dayana Reverón,Kaleena B. Dezsi,Antonio Ortiz,Joseph O. Johnson,Dung-Tsa Chen,Karla N. Ali,Sean J. Yoder,Daniel Jeong,Mokenge P. Malafa,Pamela Hodul,Kun Jiang,Barbara A. Centeno,Mahmoud A. Abdalah,Jodi A. Balasi,Alexandra F. Tassielli,Bhaswati Sarcar,Jamie K. Teer,Gina M. DeNicola,Jennifer B. Permuth,Jason B. Fleming +20 more
TL;DR: The authors report the feasibility of generating, expanding, and enumerating viable patient-derived intraductal papillary mucinous neoplasm (IPMN) tumor and normal pancreatic organoids from fresh and cryopreserved resected tissue.
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In vivo IL-12/IL-23p40 neutralization blocks Th1/Th17 response after allogeneic hematopoietic cell transplantation.
Joseph Pidala,Francisca Beato,Jongphil Kim,Brian C. Betts,Heather S.L. Jim,Elizabeth M. Sagatys,John E. Levine,James L.M. Ferrara,Umut Ozbek,Ernesto Ayala,Marco L. Davila,Hugo F. Fernandez,Teresa Field,Mohamed A. Kharfan-Dabaja,Divis K. Khaira,Farhad Khimani,Frederick L. Locke,Asmita Mishra,Michael Nieder,Taiga Nishihori,Lia Perez,Marcie L. Riches,Claudio Anasetti +22 more
TL;DR: These data provide first evidence that IL-12/IL-23p40 neutralization can polarize donor anti-host alloresponse in vivo and provide initial clinical efficacy evidence to be tested in subsequent trials.
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