Francesco Morelli
International Institute of Minnesota
18 Papers
308 Citations
Francesco Morelli is an academic researcher from International Institute of Minnesota. The author has contributed to research in topics: Apoptosis & Downregulation and upregulation. The author has an hindex of 10, co-authored 18 publications.
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Papers
Multiplex semi-quantitative reverse transcriptase-polymerase chain reaction of low abundance neuronal mRNAs.
TL;DR: A RT-PCR assay which allows the simultaneous detection and semi-quantitation of several transcripts (multiplex) and normalization with respect to HPRT cDNA allows to estimate the relative abundance of each target mRNA.
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Porin from Pseudomonas aeruginosa induces apoptosis in an epithelial cell line derived from rat seminal vesicles.
Elisabetta Buommino,Francesco Morelli,Salvatore Metafora,Fabio Rossano,Brunella Perfetto,Adone Baroni,Maria Antonietta Tufano +6 more
TL;DR: Porin induced in vitro the classic morphological and biochemical signs of apoptosis in an epithelial cell line derived from the rat seminal vesicle secretory epithelium and the programmed cell death (PCD) was p53 independent and associated with significant decrease ofbcl-2 expression, a marked increase of c-myctranscriptional activity, and an absence of the mRNA coding for tissue transglutaminase.
A recombinant MnSOD is radioprotective for normal cells and radiosensitizing for tumor cells
Antonella Borrelli,Antonella Schiattarella,Roberto Mancini,Brunello Morrica,Vincenzo Cerciello,Maria Mormile,Valentina D’Alesio,Laura Bottalico,Francesco Morelli,Maria D'Armiento,Francesco Paolo D'Armiento,Aldo Mancini +11 more
TL;DR: The data suggest that rMnSOD deserves to be considered as a pharmaceutical tool for making radiotherapy more selective on cancer cells and to prevent and/or cure the accidental damage derived from exposure to ionizing radiation.
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Early upregulation of medium neurofilament gene expression in developing spinal cord of the wobbler mouse mutant
Roberto Pernas-Alonso,Anne E. Schaffner,Carla Perrone-Capano,Antonella Orlando,Francesco Morelli,Carl T. Hansen,Jeffery L. Barker,Bruno Esposito,Francesca Cacucci,Umberto di Porzio +9 more
TL;DR: This study provides novel insights into the nature of the wobbler defect, strengthening the hypothesis that neurofilament accumulation plays a pivotal role in the etiopathogenesis of motoneuron degeneration.
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Prognostic value of human telomerase reverse transcriptase gene expression in oral carcinogenesis.
Giuseppe Pannone,S. De Maria,Rosanna Zamparese,Salvatore Metafora,Rosario Serpico,Francesco Morelli,Corrado Rubini,E. Farina,Maria Cartenì,Stefania Staibano,G. De Rosa,Lorenzo Lo Muzio,Pantaleo Bufo +12 more
TL;DR: It is demonstrated that there is no significant relationship between hTERT expression and classical clinico-pathological parameters or survival of OSCC patients, and survival analysis showed both overexpressing cases and lower survival rate in the early stage of OS CC.