Francesca Mandrelli
Max Planck Society
28 Papers
105 Citations
Francesca Mandrelli is an academic researcher from Max Planck Society. The author has contributed to research in topics: Enantioselective synthesis & Catalysis. The author has an hindex of 3, co-authored 28 publications.
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Papers
Catalytic Asymmetric Synthesis of Unprotected β2-Amino Acids
TL;DR: In this article, a scalable, catalytic one-pot approach to enantiopure and unmodified β2-amino acids is presented, where a newly developed confined imidodiphosphorimidate (IDPi) catalyzes a broadly applicable reaction of diverse bis-silyl ketene acetals with a silylated aminomethyl ether, followed by hydrolytic workup, to give free β2amino acid in high yields, purity and enantioselectivity.
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Deracemizing α-Branched Carboxylic Acids by Catalytic Asymmetric Protonation of Bis-Silyl Ketene Acetals with Water or Methanol.
TL;DR: This work reports a highly enantioselective catalytic protonation of bis-silyl ketene acetals, which delivers α-branched carboxylic acids, including non-steroidal anti-inflammatory arylpropionic acids such as Ibuprofen, in high enantiomeric purity and high yields.