Frances M. Richards
University of Cambridge
90 Papers
952 Citations
Frances M. Richards is an academic researcher from University of Cambridge. The author has contributed to research in topics: Von Hippel–Lindau disease & Pancreatic cancer. The author has an hindex of 41, co-authored 85 publications. Previous affiliations of Frances M. Richards include Aston University & University of Birmingham.
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Papers
Combenefit: an interactive platform for the analysis and visualization of drug combinations.
Giovanni Y. Di Veroli,Chiara Fornari,Dennis Wang,Severine Mollard,Jo L. Bramhall,Frances M. Richards,Duncan I. Jodrell +6 more
TL;DR: This paper presents Combenefit, new free software tool that enables the visualization, analysis and quantification of drug combination effects in terms of synergy and/or antagonism, and provides laboratory scientists with an easy and systematic way to analyze their data.
Familial gastric cancer: overview and guidelines for management*
Carlos Caldas,Fátima Carneiro,Henry T. Lynch,Jun Yokota,Georgia L. Wiesner,Steven M. Powell,Frank R. Lewis,David G. Huntsman,Paul D.P. Pharoah,Janusz Jankowski,Patrick MacLeod,Holger Vogelsang,Gisela Keller,Ken G M Park,Frances M. Richards,Eamonn R. Maher,Simon A. Gayther,Carla Oliveira,Nicola Grehan,Derek Wight,Raquel Seruca,Franco Roviello,Bruce A.J. Ponder,Charles E. Jackson +23 more
TL;DR: A group of geneticists, gastroenterologists, surgeons, oncologists, pathologists, and molecular biologists gathered to produce consensus statements and guidelines for familial gastric cancer confirmed that the gastric cancers were all of the diffuse type.
538
Germline mutations in the Von Hippel-Lindau disease (VHL) gene in families from North America, Europe, and Japan.
Berton Zbar,Takeshi Kishida,F. Chen,Laura S. Schmidt,Eamonn R. Maher,Frances M. Richards,P A Crossey,Andrew R. Webster,Nabeel A. Affara,Malcolm A. Ferguson-Smith,Hiltrud Brauch,Damjan Glavač,Hartmut P. H. Neumann,Sam Tisherman,John J. Mulvihill,David J. Gross,Taro Shuin,Jean M. Whaley,Berndt Seizinger,Nickolai Kley,Sylviane Olschwang,Cécile Boisson,Stéphane Richard,C.H.M. Lips,W. Marston Linehan,Michael I. Lerman +25 more
TL;DR: The catalog of VHL germline mutations with phenotype information should be useful for diagnostic and prognostic studies of V HL and for studies of genotype‐phenotype correlations in VHL.
494
•Journal Article
Somatic inactivation of the VHL gene in Von Hippel-Lindau disease tumors.
Amanda Prowse,Andrew R. Webster,Frances M. Richards,Stéphane Richard,Sylviane Olschwang,F. Resche,Nabeel A. Affara,Eamonn R. Maher +7 more
TL;DR: This work investigates the mechanism of tumorigenesis in VHL disease tumors to determine whether there were differences between tumor types or classes of germ-line mutations, and reports the first report of somatic methylation in a familial cancer syndrome.
241
Phenotypic expression in von Hippel-Lindau disease: correlations with germline VHL gene mutations.
Eamonn R. Maher,Andrew R. Webster,Frances M. Richards,Jane Green,P A Crossey,S. J. Payne,Anthony T. Moore +6 more
TL;DR: Large deletions and mutations predicted to cause a truncated protein were associated with a lower risk of phaeochromocytoma than missense mutations, suggesting that specific VHL mutations may be associated with different tumour susceptibility risks.
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