Florian Holsboer
Max Planck Society
930 Papers
12.1K Citations
Florian Holsboer is an academic researcher from Max Planck Society. The author has contributed to research in topics: Corticotropin-releasing hormone & Glucocorticoid receptor. The author has an hindex of 151, co-authored 929 publications. Previous affiliations of Florian Holsboer include University of Texas Southwestern Medical Center & Ludwig Maximilian University of Munich.
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Papers
Ageing alters intrahypothalamic release patterns of vasopressin and oxytocin in rats.
Martin E. Keck,Martin Hatzinger,Carsten T. Wotjak,Rainer Landgraf,Florian Holsboer,Inga D. Neumann +5 more
TL;DR: The results indicate age‐related changes in the HNS and HPA axis with an enhanced basal activity opposed to a blunted response to stressors with increasing age.
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Cross-fostering and cross-breeding of HAB and LAB rats: a genetic rat model of anxiety.
TL;DR: The extremely divergent anxiety levels of HAB and LAB rats are maintained during their whole lives and are determined genetically, rather than being learned, thus confirming a genetic basis of the differences in anxiety.
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Effects of pulsatile cortisol infusion on sleep‐EEG and nocturnal growth hormone release in healthy men
TL;DR: The pulsatile cortisol administration augmented the total amount of plasma GH concentrations due to an increase of GH release before sleep onset, and during the second half of the night, while the GH surge at sleep onset remained unchanged.
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Proteomic and Metabolomic Profiling of a Trait Anxiety Mouse Model Implicate Affected Pathways
Yaoyang Zhang,Michaela D. Filiou,Stefan Reckow,Philipp Gormanns,Giuseppina Maccarrone,Melanie S. Kessler,Elisabeth Frank,Boris Hambsch,Florian Holsboer,Rainer Landgraf,Christoph W. Turck +10 more
TL;DR: The data demonstrate that the high anxiety-related behavior and low anxiety- related behavior mouse model is a valuable tool for anxiety disorder drug discovery efforts.
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γ‐Glutamylglutamine and Taurine Concentrations Are Decreased in the Cerebrospinal Fluid of Drug‐Naive Patients with Schizophrenic Disorders
Kim Q. Do,Christoph J. Lauer,Wolfgang Schreiber,Markus Zollinger,Ursula Gutteck-Amsler,Michel Cuenod,Florian Holsboer +6 more
TL;DR: Findings support the notion that the glutamatergic system is affected in schizophrenic disorders and underscore the need to apply rigid bioanalytical techniques and use drug‐naive patients to gain in‐depth information on the pathophysiology of brain disorders such as schizophrenia.
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