Florian Holsboer
Max Planck Society
930 Papers
12.1K Citations
Florian Holsboer is an academic researcher from Max Planck Society. The author has contributed to research in topics: Corticotropin-releasing hormone & Glucocorticoid receptor. The author has an hindex of 151, co-authored 929 publications. Previous affiliations of Florian Holsboer include University of Texas Southwestern Medical Center & Ludwig Maximilian University of Munich.
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Papers
Heterodimerization between mineralocorticoid and glucocorticoid receptor: A new principle of glucocorticoid action in the CNS
TL;DR: It is demonstrated that heterodimerization of MR and GR is a hitherto unrecognized principle for the transcriptional regulation of glucocorticoid-responsive genes in tissue coexpressing these receptors.
Suppressive effect of mirtazapine on the HPA system in acutely depressed women seems to be transient and not related to antidepressant action
S. Horstmann,T. Dose,Susanne Lucae,Stefan Kloiber,Andreas Menke,Johannes M. Hennings,Derek Spieler,Manfred Uhr,Florian Holsboer,Marcus Ising +9 more
TL;DR: The results suggest that short-term administration of mirtazapine has immediate but only transient suppressive effects on the HPA system predominantly in women and confirm that dex/CRH tests can be used as predictors of clinical course also under mirtzapine treatment.
Haloperidol-induced cell death--mechanism and protection with vitamin E in vitro.
TL;DR: It is suggested that haloperidol induces necrotic cell death in which free radicals play a major role.
Rapid eye movement-related brain activation in human sleep: a functional magnetic resonance imaging study.
Renate Wehrle,Michael Czisch,Christian Kaufmann,Thomas C. Wetter,Florian Holsboer,Dorothee P. Auer,Thomas Pollmächer +6 more
TL;DR: This pilot study shows distinct magnetic resonance imaging signal increases in the posterior thalamus and occipital cortex in close temporal relationship to rapid eye movements during human rapid eye movement sleep, consistent with cell recordings in animal experiments and demonstrate that functional magnetic resonance Imaging can be utilized to detect ponto-geniculo-occipital-like activity in humans.
ABCB1 gene variants and antidepressant treatment outcome: A meta-analysis.
Barbara Breitenstein,Tanja Brückl,Marcus Ising,Bertram Müller-Myhsok,Florian Holsboer,Darina Czamara +5 more
TL;DR: A meta‐analysis of 16 pharmacogenetic studies focused on the association of ABCB1 variants and antidepressant treatment outcome in patients with MD found that SNP rs2032583 showed a nominally significant association across all studies and a significant Bonferroni‐corrected association among inpatients.