Florian Holsboer
Max Planck Society
930 Papers
12.1K Citations
Florian Holsboer is an academic researcher from Max Planck Society. The author has contributed to research in topics: Corticotropin-releasing hormone & Glucocorticoid receptor. The author has an hindex of 151, co-authored 929 publications. Previous affiliations of Florian Holsboer include University of Texas Southwestern Medical Center & Ludwig Maximilian University of Munich.
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Papers
A Polymorphism in the Crhr1 Gene Determines Stress Vulnerability in Male Mice
Christiana Labermaier,Christine Kohl,Jakob Hartmann,Christian Devigny,Andre Altmann,Peter Weber,Janine Arloth,Carina Quast,Klaus V. Wagner,Sebastian H. Scharf,L. Czibere,Regina Widner-Andrä,Julia Brenndörfer,Rainer Landgraf,Felix Hausch,Kenneth A. Jones,Marianne B. Müller,Manfred Uhr,Florian Holsboer,Elisabeth B. Binder,Mathias V. Schmidt +20 more
TL;DR: The data support that the described gene × stress exposure interaction in this animal model is based on naturally occurring genetic variations in the Crhr1 gene associated with enhanced CRHR1-mediated signaling, and suggest that patients with a specific genetic predisposition in theCRHR1 gene together with an exposure to chronic stress may benefit from a treatment selectively antagonizing CRHR 1 hyperactivity.
Cellular Localization of Interleukin 6 mRNA and Interleukin 6 Receptor mRNA in Rat Brain
TL;DR: It is proposed that the cytokine IL‐6 is expressed constitutively in discrete regions of the CNS and that it is involved in the mechanisms coordinating metabolic, behavioural and neuroendocrine changes not only during illness but also under normal physiological conditions.
Steroid Effects on Central Neurons and Implications for Psychiatric and Neurological Disorders
TL;DR: The combined DEX-CRH test is the best neuroendocrine tool currently available for identifying HPA abnormalities in psychiatric patients and various corticosteroids, their biosynthetic precursors and their metabolites have differentiable effects on the sleep EEG, which can be attributed to their mode of action.
Estimating the heritability of reporting stressful life events captured by common genetic variants
Robert Power,T. Wingenbach,Sarah Cohen-Woods,Rudolf Uher,Mandy Y.M. Ng,Amy W. Butler,Marcus Ising,Nicholas John Craddock,Michael John Owen,Ania Korszun,Lisa Jones,Ian Jones,Michael Gill,John P. Rice,Wolfgang Maier,Astrid Zobel,Ole Mors,Anna Placentino,Marcella Rietschel,Susanne Lucae,Florian Holsboer,Elisabeth B. Binder,Robert Keers,Ferderica Tozzi,Pierandrea Muglia,Gerome Breen,Ian W. Craig,Bertram Müller-Myhsok,James L. Kennedy,John Strauss,John B. Vincent,Cathryn M. Lewis,Anne Farmer,Peter McGuffin +33 more
TL;DR: These results provide independent validation from molecular data for the heritability of reporting environmental measures, and show that this heritability is in part due to both common variants and the confounding effect of personality.
Behavioural performance in three substrains of mouse strain 129
TL;DR: Three 129 mouse substrains were tested in the Morris water maze, the open field, the plus maze and two tests assessing motor co-ordination and it was found that the 129/J substrain substantial behavioural deficits were identified.