Florian Holsboer
Max Planck Society
930 Papers
12.1K Citations
Florian Holsboer is an academic researcher from Max Planck Society. The author has contributed to research in topics: Corticotropin-releasing hormone & Glucocorticoid receptor. The author has an hindex of 151, co-authored 929 publications. Previous affiliations of Florian Holsboer include University of Texas Southwestern Medical Center & Ludwig Maximilian University of Munich.
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Papers
Conditional CRH overexpressing mice: an animal model for stress-elicited pathologies and treatments that target the central CRH system.
Ailing Lu,M. A. Steiner,Nigel Whittle,Annette M. Vogl,S. M. Walser,M Ableitner,Damian Refojo,Marc Ekker,John L.R. Rubenstein,Günter K. Stalla,Nicolas Singewald,Florian Holsboer,Carsten T. Wotjak,Wolfgang Wurst,Jan M. Deussing +14 more
TL;DR: Conditional CRH overexpressing mice are used as an animal model for stress-elicited pathologies and treatments that target the central CRH system.
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Proliferation rates and gene expression profiles in human lymphoblastoid cell lines from patients with depression characterized in response to antidepressant drug therapy.
Jörg Breitfeld,Catharina Scholl,Michael Steffens,Kerstin Brandenburg,Kristina Probst-Schendzielorz,O Efimkina,David Gurwitz,Marcus Ising,Florian Holsboer,Susanne Lucae,Julia C. Stingl,Julia C. Stingl +11 more
TL;DR: Potential gene expression biomarkers eventually being useful as baseline predictors or as longitudinal targets in antidepressant therapy are identified.
Mice selected for extremes in stress reactivity reveal key endophenotypes of major depression: A translational approach
Jan Michael Heinzmann,Stefan Kloiber,Gabriele Ebling-Mattos,Maximilian Bielohuby,Rupert Palme,Florian Holsboer,Manfred Uhr,Marcus Ising,Chadi Touma,Silja McIlwrick +9 more
TL;DR: The SR mouse model can serve as a valuable tool to elucidate HPA axis-related mechanisms underlying affective disorders and a stratification of MD patients according to their HPAaxis-related neuroendocrine function should be considered for clinical research and treatment.
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The Munich vulnerability study on affective disorders: premorbid psychometric profile of affected individuals.
TL;DR: A longitudinal high‐risk study was conducted to identify psychometric vulnerability markers for affective disorders and found three markers were associated with vulnerability to major depressive disorders.
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Prolactin but not ACTH increases during sodium lactate-induced panic attacks
TL;DR: Prolactin release was significantly elevated in panickers compared with non-panickers, whereas ACTH secretion was not activated at all, although this differential stress response needs further investigation.
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