Florian Freudenberg
Goethe University Frankfurt
44 Papers
146 Citations
Florian Freudenberg is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Hippocampus & Medicine. The author has an hindex of 16, co-authored 34 publications. Previous affiliations of Florian Freudenberg include Freudenberg Group & University of Würzburg.
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Papers
Neuronal nitric oxide synthase (NOS1) and its adaptor, NOS1AP, as a genetic risk factors for psychiatric disorders.
TL;DR: The evidence for the role of NO in psychiatric disorders is reviewed by focusing on the human NOS1 gene as well as biomarker studies, suggesting that genetically driven reduced NO signaling in the prefrontal cortex is associated with schizophrenia and cognition.
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The role of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in depression: Central mediators of pathophysiology and antidepressant activity?
TL;DR: Preclinical evidence supports an important involvement of AMPA receptor-dependent signaling and plasticity in the pathophysiology and treatment of depression and discusses a possible central role for AMPA receptors in the Pathophysiology, course and Treatment of depression.
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Dopamine in the orbitofrontal cortex regulates operant responding under a progressive ratio of reinforcement in rats.
TL;DR: The data indicate that orbitofrontal dopamine is necessary for reward-related instrumental behavior under conditions of increasing instrumental effort.
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Select overexpression of homer1a in dorsal hippocampus impairs spatial working memory
Tansu Celikel,Verena Marx,Florian Freudenberg,Aleksandar R. Zivkovic,Evgeny Resnik,Mazahir T. Hasan,Pawel Licznerski,Pavel Osten,Andrej Rozov,Peter H. Seeburg,Martin K. Schwarz +10 more
TL;DR: It is reported that sustained overexpression of H1aV impaired spatial working but not reference memory, and impairments generated by sustained high Homer1a levels identify a requirement for long Homer forms in synaptic plasticity and temporal encoding of spatial memory.
Dissociation of impulsivity and aggression in mice deficient for the ADHD risk gene Adgrl3: Evidence for dopamine transporter dysregulation.
Niall Mortimer,Tatjana Ganster,Aet O'Leary,Sandy Popp,Florian Freudenberg,Andreas Reif,María Soler Artigas,M. Ribasés,Josep Antoni Ramos-Quiroga,Klaus-Peter Lesch,Olga Rivero +10 more
TL;DR: This study further validates Adgrl3 constitutive knockout mice as an experimental model of ADHD while providing neuroanatomical targets for future studies involving ADGRL3 modified models.
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