Florent Dumont
Paris Descartes University
7 Papers
Florent Dumont is an academic researcher from Paris Descartes University. The author has contributed to research in topics: Gene expression & Transcriptome. The author has an hindex of 7, co-authored 7 publications.
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Papers
Highly Dynamic Transcriptional Signature of Distinct Macrophage Subsets during Sterile Inflammation, Resolution, and Tissue Repair
Tamas Varga,Rémi Mounier,Attila Horvath,Sylvain Cuvellier,Florent Dumont,Szilárd Póliska,Hamida Ardjoune,Gaëtan Juban,Laszlo Nagy,Bénédicte Chazaud +9 more
TL;DR: The results show the highly dynamic nature of the macrophage response at the molecular level after an acute tissue injury and subsequent repair, and associate a specific signature of macrophages to predictive specialized functions ofmacrophages at each step of tissue injury/repair.
Use of Whole‐Blood Transcriptomic Profiling to Highlight Several Pathophysiologic Pathways Associated With Response to Rituximab in Patients With Rheumatoid Arthritis: Data From a Randomized, Controlled, Open‐Label Trial
Jérémie Sellam,Sandrine Marion-Thore,Florent Dumont,Sébastien Jacques,Henri-Jean Garchon,Stéphanie Rouanet,Yassine Taoufik,Houria Hendel-Chavez,Jean Sibilia,Jacques Tebib,Xavier Le Loët,Bernard Combe,Maxime Dougados,Xavier Mariette,Gilles Chiocchia +14 more
TL;DR: To identify a molecular signature that could be predictive of the clinical response to rituximab (RTX) and elucidate the transcriptomic changes after RTX therapy in patients with rheumatoid arthritis (RA), with the use of whole‐blood transcriptomic profiling.
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AhR-deficiency as a cause of demyelinating disease and inflammation.
Ludmila Juricek,Ludmila Juricek,Julie Carcaud,Julie Carcaud,Alice Pelhaitre,Alice Pelhaitre,Thorfinn T. Riday,Thorfinn T. Riday,Aline Chevallier,Aline Chevallier,Justine Lanzini,Justine Lanzini,Nicolas Auzeil,Nicolas Auzeil,Olivier Laprévote,Olivier Laprévote,Florent Dumont,Sébastien Jacques,Frank Letourneur,Charbel Massaad,Charbel Massaad,Cendra Agulhon,Cendra Agulhon,Robert Barouki,Robert Barouki,Mathieu Beraneck,Mathieu Beraneck,Xavier Coumoul,Xavier Coumoul +28 more
TL;DR: The AhR-knockout phenotype develops during early infancy together with deficits in visual-information-processing which are associated with an altered optic nerve myelin sheath, and a mechanism by which environmental pollutants might influence CNS myelination is identified and suggested as a relevant drug target for demyelinating diseases.
Monocyte-derived dendritic cells from HLA-B27+ axial spondyloarthritis (SpA) patients display altered functional capacity and deregulated gene expression
Alice Talpin,Alice Talpin,Félicie Costantino,Félicie Costantino,Nelly Bonilla,Ariane Leboime,Franck Letourneur,Sébastien Jacques,Florent Dumont,Sonia Amraoui,Charles-Antoine Dutertre,Henri-Jean Garchon,Maxime Breban,Maxime Breban,Gilles Chiocchia,Gilles Chiocchia +15 more
TL;DR: The stimulatory capacity of allogeneic CD4+ T cells by MD-DCs from SpA patients was decreased and the Wnt signaling pathway appeared as deregulated in SpA MD- DCs, a finding which may be connected to Th17-driven inflammatory responses.
Molecular insight into thiopurine resistance: transcriptomic signature in lymphoblastoid cell lines
Laurent Chouchana,Ana A. Fernández-Ramos,Ana A. Fernández-Ramos,Florent Dumont,Catherine Marchetti,Catherine Marchetti,Irène Ceballos-Picot,Philippe Beaune,David Gurwitz,Marie-Anne Loriot,Marie-Anne Loriot +10 more
TL;DR: A comprehensive pathway analysis of the genes differentially expressed between resistant and sensitive cell lines indicated a role for cell cycle and DNA mismatch repair system in thiopurine resistance.