Florence Serres
University of Oxford
15 Papers
161 Citations
Florence Serres is an academic researcher from University of Oxford. The author has contributed to research in topics: Receptor & Serotonin. The author has an hindex of 9, co-authored 15 publications. Previous affiliations of Florence Serres include Mansfield University of Pennsylvania & Loyola University Chicago.
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Papers
5-HT2A receptors stimulate ACTH, corticosterone, oxytocin, renin, and prolactin release and activate hypothalamic CRF and oxytocin-expressing cells.
TL;DR: The combined neuroanatomical and pharmacological observations suggest that the neuroendocrine responses to DOI are mediated by activation of neurons in the hypothalamic paraventricular nucleus and associated circuitry.
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S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models
Anne Dekeyne,Clotilde Mannoury la Cour,Alain Gobert,Mauricette Brocco,Françoise Lejeune,Florence Serres,Trevor Sharp,Annie Daszuta,Amélie Soumier,Mariusz Papp,Jean-Michel Rivet,Gunnar Flik,Thomas I. F. H. Cremers,Olivier Muller,Gilbert Lavielle,Millan Mark +15 more
TL;DR: In vitro and in vivo, the novel benzourea derivative, S32006 is a potent 5-HT2C receptor antagonist, and possesses antidepressant and anxiolytic properties in diverse rodent models.
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Long-term fluoxetine produces behavioral anxiolytic effects without inhibiting neuroendocrine responses to conditioned stress in rats.
Yahong Zhang,D. K. Raap,Francisca Garcia,Florence Serres,Qing Ma,George Battaglia,Louis D. Van der Kar +6 more
TL;DR: It is suggested that neuroadaptive changes induced by sustained inhibition of serotonin (5-HT) reuptake, contribute to the mechanism of the anxiolytic effects of fluoxetine, in contrast to the neuroendocrine responses to conditioned stress, which are not affected by these neuro Adaptive changes.
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Evidence that G(z)-proteins couple to hypothalamic 5-HT(1A) receptors in vivo.
Florence Serres,Qian Li,Francisca Garcia,D. K. Raap,George Battaglia,Nancy A. Muma,L.D. Van de Kar +6 more
TL;DR: P pertussis toxin-sensitive Gi/Go-proteins do not mediate the 5-HT1A receptor-mediated increase in ACTH and oxytocin secretion, and these studies provide the firstin vivo evidence for a key role of Gz- Proteins in coupling hypothalamic 5- HT1Areceptors to effector mechanisms.
69
S32504, a Novel Naphtoxazine Agonist at Dopamine D3/D2 Receptors: III. Actions in Models of Potential Antidepressive and Anxiolytic Activity in Comparison with Ropinirole
Millan Mark,Mauricette Brocco,Mariusz Papp,Florence Serres,Christophe Drieu La Rochelle,Trevor Sharp,Jean-Louis Peglion,Anne Dekeyne +7 more
TL;DR: In forced-swim tests in mice and rats, the novel S32504 displays a broad and distinctive profile of activity in models of potential antidepressive and anxiolytic properties and did not modify corticolimbic levels of serotonin2A receptors or brain-derived neurotrophic factor.
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