Flávia Nathiely Silveira Fachel
Universidade Federal do Rio Grande do Sul
33 Papers
26 Citations
Flávia Nathiely Silveira Fachel is an academic researcher from Universidade Federal do Rio Grande do Sul. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 7, co-authored 21 publications.
Author Tools
Chat about Author
Papers
Box-Behnken design optimization of mucoadhesive chitosan-coated nanoemulsions for rosmarinic acid nasal delivery-In vitro studies.
Flávia Nathiely Silveira Fachel,Bruna Medeiros-Neves,Morgana Dal Prá,Roselena Silvestri Schuh,Kleyton Santos Veras,Valquiria Linck Bassani,Letícia Scherer Koester,Amélia T. Henriques,Elizandra Braganhol,Helder Ferreira Teixeira +9 more
TL;DR: Optimized chitosan-coated RA nanoemulsions presented adequate physicochemical characteristics, high mucoadhesive potential, prolonged drug release, and long-lasting permeation time with a higher RA penetration/retention through porcine nasal mucosa.
82
An overview of the neuroprotective potential of rosmarinic acid and its association with nanotechnology-based delivery systems: A novel approach to treating neurodegenerative disorders
Flávia Nathiely Silveira Fachel,Roselena Silvestri Schuh,Kleyton Santos Veras,Valquiria Linck Bassani,Letícia Scherer Koester,Amélia T. Henriques,Elizandra Braganhol,Helder Ferreira Teixeira +7 more
TL;DR: An overview of the neuroprotective potential of rosmarinic acid (RA) and the use of nanotechnology as a novel approach to treating ND are presented and nanotechnology‐based therapy emerges as a promising strategy for RA.
55
Compatibility study of rosmarinic acid with excipients used in pharmaceutical solid dosage forms using thermal and non-thermal techniques
Kleyton Santos Veras,Flávia Nathiely Silveira Fachel,Vanessa Pittol,Keth Ribeiro Garcia,Valquiria Linck Bassani,Venina dos Santos,Amélia T. Henriques,Helder Ferreira Teixeira,Letícia Scherer Koester +8 more
TL;DR: Evaluated the compatibility of RA with excipients commonly used in solid dosage forms at a 1:1 (RA:excipient) ratio using differential scanning calorimetry and thermogravimetry to demonstrate that RA was compatible with MCC and PVP.
31
Chitosan-coated rosmarinic acid nanoemulsion nasal administration protects against LPS-induced memory deficit, neuroinflammation, and oxidative stress in Wistar rats.
Flávia Nathiely Silveira Fachel,Luana Roberta Michels,Juliana Hofstatter Azambuja,Gabriela Spies Lenz,Nicolly Espindola Gelsleichter,Marcelo Endres,Juliete Nathali Scholl,Roselena Silvestri Schuh,Alethea Gatto Barschak,Fabrício Figueiró,Valquiria Linck Bassani,Amélia T. Henriques,Letícia Scherer Koester,Helder Ferreira Teixeira,Elizandra Braganhol +14 more
TL;DR: It is proved for the first time that the RA CNE nasal administration elicits a neuroprotective effect against LPS-induced damage, which was associated with increased 1.6 times recognition index, decreased 5.0 and 1.9 times in GFAP+ cell count and CD11b expression, respectively.
31
Glioprotective Effect of Chitosan-Coated Rosmarinic Acid Nanoemulsions Against Lipopolysaccharide-Induced Inflammation and Oxidative Stress in Rat Astrocyte Primary Cultures.
Flávia Nathiely Silveira Fachel,Morgana Dal Prá,Juliana Hofstatter Azambuja,Marcelo Endres,Valquiria Linck Bassani,Letícia Scherer Koester,Amélia T. Henriques,Alethea Gatto Barschak,Helder Ferreira Teixeira,Elizandra Braganhol +9 more
TL;DR: Overall, the findings indicate for the first time the RA CNE glioprotective potential, associated with an increase in cell viability and proliferation, a preventive effect on cellular death by necrosis, migratory ability and hypertrophic reactive astrocytes, and the reparation ofAstrocyte redox state.
30