Flavia Barragán
University of Barcelona
5 Papers
128 Citations
Flavia Barragán is an academic researcher from University of Barcelona. The author has contributed to research in topics: Ruthenium & Covalent radius. The author has an hindex of 5, co-authored 5 publications.
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Papers
Covalent radii revisited
Beatriz Cordero,Verónica Gómez,Ana E. Platero-Prats,Marc Revés,Jorge Echeverría,Eduard Cremades,Flavia Barragán,Santiago Alvarez +7 more
TL;DR: A new set of covalent atomic radii has been deduced from crystallographic data for most of the elements with atomic numbers up to 96 and shows a well behaved periodic dependence that allows us to interpolate a few radii for elements for which structural data is lacking.
Somatostatin Subtype-2 Receptor-Targeted Metal-Based Anticancer Complexes
Flavia Barragán,Dolors Carrion-Salip,Irene Gómez-Pinto,Alejandro González-Cantó,Peter J. Sadler,Rafael de Llorens,Virtudes Moreno,Carlos González,Anna Massaguer,Vicente Marchán +9 more
TL;DR: New insights are provided into the effect of receptor-binding peptide conjugation on the activity of metal-based anticancer drugs, and the potential of such hybrid compounds to target tumor cells specifically is demonstrated.
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Conjugation of a Ru(II) arene complex to neomycin or to guanidinoneomycin leads to compounds with differential cytotoxicities and accumulation between cancer and normal cells.
Ariadna Grau-Campistany,Anna Massaguer,Dolors Carrion-Salip,Flavia Barragán,Gerard Artigas,Paula López-Senín,Virtudes Moreno,Vicente Marchán +7 more
TL;DR: Differences in cytotoxic activity and cellular accumulation between cancer and normal cells open the way to the creation of more selective, less toxic anticancer metallodrugs by conjugating cytot toxic metal-based complexes such as ruthenium(II) arene derivatives to guanidinoglycosides.
Solid-phase synthesis and DNA binding studies of dichloroplatinum(ii) conjugates of dicarba analogues of octreotide as new anticancer drugs.
TL;DR: The first dichloroplatinum conjugates of dicarba analogues of octreotide have been efficiently synthesized following a stepwise solid-phase approach and emulate the mechanism of cisplatin since they form a 1,2-intrastrand cross-link with two consecutive guanines of an oligonucleotide.
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Photocontrolled DNA Binding of a Receptor-Targeted Organometallic Ruthenium(II) Complex
Flavia Barragán,Paula López-Senín,Luca Salassa,Soledad Betanzos-Lara,Abraha Habtemariam,Virtudes Moreno,Peter J. Sadler,Vicente Marchán +7 more
TL;DR: The lack of interaction with the peptide fragment confirms the preference of such organometallic ruthenium(II) complexes for guanine over other potential biological ligands, such as histidine or methionine amino acids.