Fiona Oliver
University of Edinburgh
9 Papers
161 Citations
Fiona Oliver is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Quantitative trait locus & Gene. The author has an hindex of 8, co-authored 9 publications.
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Papers
Analysis of the genome sequences of three Drosophila melanogaster spontaneous mutation accumulation lines.
TL;DR: The rate and properties of new spontaneous mutations in Drosophila melanogaster are inferred by carrying out whole-genome shotgun sequencing-by-synthesis of three mutation accumulation lines that had been maintained by close inbreeding for an average of 262 generations, implying that any transcription-coupled repair process is weak.
Evidence for Pervasive Adaptive Protein Evolution in Wild Mice
TL;DR: It is estimated that 57% of amino acid substitutions in murids have been driven by positive selection, and Hominids are exceptional in having low apparent levels of adaptive protein evolution.
Regulatory Variation at Glypican-3 Underlies a Major Growth QTL in Mice
Fiona Oliver,Julian K. Christians,Xiaojun Liu,Susan Rhind,Vinesh Verma,Claire Davison,Steve D.M. Brown,Paul Denny,Peter D. Keightley +8 more
TL;DR: It is shown that small changes in gene expression can have substantial phenotypic effects, indicating that genes involved in Mendelian diseases also contribute to complex trait variation.
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Test of candidate gene–quantitative trait locus association applied to fatness in mice
Peter D. Keightley,Kenneth H Morris,Akira Ishikawa,Akira Ishikawa,Victoria M. Falconer,Fiona Oliver +5 more
TL;DR: A randomization test for overall contribution of candidate genes, based on the empirical distribution of LOD scores from a quantitative trait locus (QTL) genome scan, is proposed, which is significant for gonadal fat pad weight in males, and gives weak support for an association with the diabetes gene.
Positive and Negative Selection in Murine Ultraconserved Noncoding Elements
Daniel L. Halligan,Fiona Oliver,Jack Guthrie,Kathryn Stemshorn,Bettina Harr,Peter D. Keightley +5 more
TL;DR: There is widespread adaptation in mammalian conserved noncoding DNA elements, some of which have been implicated in the regulation of crucially important processes, including development, according to a phylogenetically independent comparison.
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