Fiona J. Carr
University of Glasgow
7 Papers
82 Citations
Fiona J. Carr is an academic researcher from University of Glasgow. The author has contributed to research in topics: Congenic & Gene. The author has an hindex of 6, co-authored 7 publications. Previous affiliations of Fiona J. Carr include Western Infirmary.
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Papers
Microarray Analysis of Rat Chromosome 2 Congenic Strains
Martin W. McBride,Fiona J. Carr,Delyth Graham,Niall H. Anderson,James S. Clark,Wai K. Lee,Fadi J. Charchar,M. Julia Brosnan,Anna F. Dominiczak +8 more
TL;DR: Genome-wide microarray expression profiling was undertaken to identify differentially expressed genes among the parental SHRSP, WKY, and congenic strain, and identified a significant reduction in expression of glutathione S-transferase &mgr;-type 2, a gene involved in the defense against oxidative stress.
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Reciprocal consomic strains to evaluate y chromosome effects.
Cervantes D. Negrin,Martin W. McBride,Hillary V. O. Carswell,Delyth Graham,Fiona J. Carr,James S. Clark,Baxter Jeffs,Niall H. Anderson,I. Mhairi Macrae,Anna F. Dominiczak +9 more
TL;DR: It is concluded that the SHRSP Y chromosome harbors a locus contributing to systolic BP, whereas no contribution to vulnerability to cerebral ischemia can be detected.
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Functional genomics in rodent models of hypertension
Martin W. McBride,Fadi J. Charchar,Delyth Graham,William H. Miller,Pamela Strahorn,Fiona J. Carr,Anna F. Dominiczak +6 more
TL;DR: Recent developments in rat genome resources and advancement in statistical and bioinformatic methods will facilitate the identification of major gene(s) responsible for complex, polygenic traits.
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Altered Na+-K+ pump activity and plasma lipids in salt-hypertensive Dahl rats: relationship to Atp1a1 gene.
Josef Zicha,Cervantes D. Negrin,Zdena Dobešová,Fiona J. Carr,M. Vokurková,Martin W. McBRIDE,Jaroslav Kuneš,Anna F. Dominiczak +7 more
TL;DR: In conclusion, abnormal cholesterol metabolism but not the Atp1a1 gene locus might represent an important factor for both high BP and altered Na(+)-K(+) pump function in salt-hypertensive Dahl rats.
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Chromosome 2 reciprocal congenic strains to evaluate the effect of the genetic background on blood pressure
Fiona J. Carr,Cervantes D. Negrin,James S. Clark,D. I. Graham,Martin W. McBride,N.W. Anderson,Anna F. Dominiczak +6 more
TL;DR: The reciprocal congenic blood pressure showed a significantly increased baseline systolic pressure compared to the WKY, with no change in significance at the salt loaded period, and the gene(s) which contribute to blood pressure regulation in both congenic strains were successfully captured.
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