Filip Kalčic
Academy of Sciences of the Czech Republic
5 Papers
10 Citations
Filip Kalčic is an academic researcher from Academy of Sciences of the Czech Republic. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 2, co-authored 3 publications.
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Papers
Influence of the C-5 substitution in polysubstituted pyrimidines on inhibition of prostaglandin E2 production.
TL;DR: Both monoaryl- and bisarylpyrimidines were potent inhibitors of PGE2 production regardless the length of the C-5 substituent (hydrogen, methyl, n-butyl).
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Polysubstituted 4,6-bis(hetero)arylpyrimidines as dual inhibitors of nitric oxide and prostaglandin E2 production
TL;DR: Although the exact mode of action of the prepared compounds remains to be elucidated, non-toxic dual inhibitors of NO and PGE2 production may have great therapeutic benefit in treatment of various inflammation diseases and deserve further preclinical evaluation.
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Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors
Jan Skácel,S. Djukic,Ondřej Baszczyňski,Filip Kalčic,Karel Chalupsky,Jaroslav Kozak,Alexandra Dvoráková,Eva Tloušt’ová,Z. Kral'ova,Markéta Šmídková,Jan Voldřich,Michaela Rumlová,Petr Pachl,Jiří Brynda,Tereza Vuckova,Milan Fábry,Jan Snášel,Iva Pichová,Pavlina Rezacova,Helena Mertlíková-Kaiserová,Zlatko Janeba +20 more
TL;DR: In this article , a series of 30 PNP inhibitors based on acyclic nucleoside phosphonates bearing a 9-deazahypoxanthine nucleobase were evaluated.
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Mechanisms of Inhibitory Effects of Polysubstituted Pyrimidines on Prostaglandin E2 Production
Zdeněk Zídek,Viktor Kolman,Ondřej Baszczyňski,Filip Kalčic,Daniel Board,Zlatko Janeba +5 more
- 07 Aug 2019
TL;DR: The pyrimidine heterocycle represents an elemental structural motif of numerous drugs and is a central motif in the design of many new drugs.
1H NMR Profiling of Honey Bee Bodies Revealed Metabolic Differences between Summer and Winter Bees
SaetByeol Lee,Filip Kalčic,Iola F. Duarte,Dalibor Titera,Martin Kamler,Pavel Mrna,Pavel Hyršl,Jiří Danihlík,Pavel Dobeš,Martin Kunc,Anna Pudło,Jaroslav Havlik +11 more
TL;DR: The results show that the metabolites in summer and winter bees have distinctive characteristics; this information could provide new insights and support further studies on honey bee longevity and overwintering.