Fengxiang Wei
McMaster University
28 Papers
175 Citations
Fengxiang Wei is an academic researcher from McMaster University. The author has contributed to research in topics: Prostate cancer & Kinase. The author has an hindex of 13, co-authored 22 publications. Previous affiliations of Fengxiang Wei include Guangzhou Higher Education Mega Center & Jiamusi University.
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Papers
Both ERK1 and ERK2 kinases promote G2/M arrest in etoposide-treated MCF7 cells by facilitating ATM activation.
TL;DR: It is demonstrated that both ERK1 and ERK2 kinases play a role in etoposide-induced G2/M arrest by facilitating activation of the ATM pathway and suggest that a cellular threshold level of ERK kinase activity is required for the proper checkpoint activation in MCF7 cells.
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A Novel Aspect of Tumorigenesis—BMI1 Functions in Regulating DNA Damage Response
Xiaozeng Lin,Diane Ojo,Diane Ojo,Diane Ojo,Fengxiang Wei,Nicholas Wong,Nicholas Wong,Yan Gu,Yan Gu,Damu Tang,Damu Tang,Damu Tang +11 more
- 01 Dec 2015
TL;DR: The emerging role of BMI1 in DDR regulation is reviewed and its impact on BMI1-derived tumorigenesis is discussed, specifically its regulative role in DNA damage response.
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Amplification of MUC1 in prostate cancer metastasis and CRPC development.
Nicholas Wong,Pierre Major,Anil Kapoor,Fengxiang Wei,Judy Yan,Judy Yan,Tariq Aziz,Mingxing Zheng,Dulitha Jayasekera,Dulitha Jayasekera,Jean-Claude Cutz,Mathilda Jing Chow,Mathilda Jing Chow,Damu Tang,Damu Tang +14 more
TL;DR: An association of M UC1 upregulation with PC metastasis and the development of castration resistant PC (CRPC) is reported and a combination therapy involving MUC1-based immunotherapy and androgen deprivation is suggested.
Inhibition of ERK activation enhances the repair of double-stranded breaks via non-homologous end joining by increasing DNA-PKcs activation.
TL;DR: It is demonstrated that ERK reduces NHEJ-mediated repair of DSBs via attenuation of DNA-PKcs activation through inhibition of ERK activation using U0126, MEK1K97M, and knockdown of ERk1 or ERK2 enhanced ETOP-induced activation of DNA -PKcs.
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Overexpression of MUC1 and Genomic Alterations in Its Network Associate with Prostate Cancer Progression.
Xiaozeng Lin,Yan Gu,Yan Gu,Anil Kapoor,Fengxiang Wei,Tariq Aziz,Diane Ojo,Diane Ojo,Yanzhi Jiang,Michael Bonert,Bobby Shayegan,Huixiang Yang,Khalid Al-Nedawi,Khalid Al-Nedawi,Pierre Major,Damu Tang,Damu Tang +16 more
TL;DR: The association of MUC1 with castration-resistant prostate cancer (CRPC), bone metastasis, and PC recurrence is investigated and several novel β-catenin mutants are identified in PCs leading to a rapid onset of death and recurrence.
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