Fengwei Li
Chinese Academy of Sciences
12 Papers
41 Citations
Fengwei Li is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 3, co-authored 5 publications. Previous affiliations of Fengwei Li include Shandong University.
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Papers
Compartmentalized biosynthesis of mycophenolic acid
Wei Zhang,Wei Zhang,Lei Du,Zepeng Qu,Xingwang Zhang,Xingwang Zhang,Fengwei Li,Zhong Li,Feifei Qi,Xiao Wang,Yuanyuan Jiang,Ping Men,Jingran Sun,Shaona Cao,Ce Geng,Fengxia Qi,Xiaobo Wan,Xiaobo Wan,Changning Liu,Shengying Li,Shengying Li +20 more
TL;DR: This work elucidate the full biosynthetic pathway of the fungal natural product mycophenolic acid (MPA) and reveals that the MPA biosynthesis enzymes are elegantly compartmentalized; the oxygenase MpaB′ is the long-sought enzyme responsible for initiating the oxidative cleavage of the farnesyl side chain; and the subcellular localization of the acyl-coenzyme A hydrolase MPAH′ in peroxisomes is required
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Identification of oleoylethanolamide as an endogenous ligand for HIF-3α
Xiaotong Diao,Fei Ye,Mei‐Ling Zhang,Xintong Ren,Xiaoxu Tian,Jingping Lu,Xiangnan Sun,Zeng Hou,Xiaoyu Chen,Fengwei Li,J. Zhuang,Hong Ding,Chao Peng,Fraydoon Rastinejad,Cheng Luo,Dalei Wu +15 more
TL;DR: In this paper , the authors show that oleoylethanolamide (OEA), a physiological lipid known to regulate food intake and metabolism, binds selectively to HIF-3α.
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Identification and evaluation of a lipid-lowering small compound in preclinical models and in a Phase I trial.
Jiang-Hong Wang,Jing Zhao,Cong Yan,Cong Xi,Chenglin Wu,Jinbing Zhao,Fengwei Li,Yanhuai R. Ding,Rui Zhang,Shankang Qi,Xingjun Li,Chao Liu,Wanting Hou,Hong Chen,Yiping Wang,Dalei Wu,Kaixian Chen,Hualiang Jiang,He Huang,Hong Ying Liu +19 more
TL;DR: The discovery of DC371739, an indole-containing tetrahydroisoquinoline compound with promising lipid-lowering effects, and its combination with atorvastatin treatment to additively improve dyslipidemia, while providing a potential alternative therapeutic strategy for individuals with statin intolerance.
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Three pairs of surrogate redox partners comparison for Class I cytochrome P450 enzyme activity reconstitution
Xiaohui Liu,Fengwei Li,Tianjian Sun,Jiawei Guo,Xingwang Zhang,Xianliang Zheng,Lei Du,Wei Zhang,Li Ma,Sheng-Nan Li +9 more
TL;DR: In this paper , the authors compared three surrogate redox partners for P450s and showed that Sel Fdx1499/Sel FdR0978 is the most promising redox partner compared to Adx/AdR and Pdx/PdR.
Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family
Xiangnan Sun,Linqian Jing,Fengwei Li,Mei‐Ling Zhang,Xiaotong Diao,Jingjing Zhang,Fraydoon Rastinejad,Dalei Wu +7 more
TL;DR: In this paper , the authors visualize the molecular architectures of the PER-ARNT-SIM (PAS) domain protein 4 (NPAS4) and its heterodimers, finding unique architectural features and dimerization patterns relative to other members of their family.
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