Fengrun Sun
Fudan University Shanghai Medical College
18 Papers
16 Citations
Fengrun Sun is an academic researcher from Fudan University Shanghai Medical College. The author has contributed to research in topics: Medicine & Immune system. The author has an hindex of 4, co-authored 11 publications.
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Papers
Functional regulation of decidual macrophages during pregnancy.
TL;DR: This work mainly focused on the significant roles of decidual macrophages in the process of extravillous trophoblast invasion, spiral arterial remodeling, decidUAL stromal cells cultivation and immune tolerance maintenance in normal pregnancy and in pregnancy complications.
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Trophoblast-derived hyaluronan promotes the regulatory phenotype of decidual macrophages.
Songcun Wang,Fengrun Sun,Mutian Han,Yinghua Liu,Qinyan Zou,Fuxin Wang,Yu Tao,Da-Jin Li,Meirong Du,Hong Li,Rui Zhu +10 more
TL;DR: It is confirmed that higher secretion of HA by Tros could induce M2 polarization of macrophages at the maternal-fetal interface by interacting with CD44 and activating the downstream PI3K/Akt-STAT-3/STAT-6 signaling pathways.
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Tim-3+ decidual Mφs induced Th2 and Treg bias in decidual CD4+T cells and promoted pregnancy maintenance via CD132
Mengdie Li,Fengrun Sun,Yuan-Yuan Xu,Lanting Chen,Chunqin Chen,Liyuan Cui,Jinfeng Qian,Dajin Li,Songcun Wang,Meirong Du +9 more
TL;DR: In this article , the authors found that T-cell immunoglobulin mucin-3 (Tim-3) plays roles in functional regulation of both adaptive and innate immune cells and is greatly involved in many diseases.
Bidirectional regulation between 1st trimester HTR8/SVneo trophoblast cells and in vitro differentiated Th17/Treg cells suggest a fetal‐maternal regulatory loop in human pregnancy
Songcun Wang,Jinfeng Qian,Fengrun Sun,Mengdie Li,Jiangfeng Ye,Ming-Qing Li,Meirong Du,Da-Jin Li +7 more
TL;DR: During normal pregnancy, delicate crosstalk is established between fetus‐derived trophoblasts and maternal immune cells to ensure maternal‐fetal tolerance and successful placentation.
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Tim-3/CTLA-4 pathways regulate decidual immune cells-extravillous trophoblasts interaction by IL-4 and IL-10.
TL;DR: In this article, the authors used immortalized human first trimester extravillous trophoblast cells and primary EVTs and found that DICs promote EVT function and placental development, and IL-4 and IL10 could rescue the adverse effects of targeting Tim-3 and CTLA-4 on the pregnancy outcome.
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