Based on the phosphorylated reaction, an efficient general synthetic approach that provide facile, rapid and cheap access to a wide range of novel phosphoramide derivatives of paeonol has been deve...

Synthesis and Characterization of Phosphoramide Piperazine Analogs of Paeonol

Progress in phosphorylation of natural products

6-O-Phosphorylated pyridazine-3(2H)-one derivatives were conveniently prepared by a facile method. Maleic hydrazide was prepared by the condensation of maleic anhydride with 85% hydrazine hydrate. ...

Highly Chemoselective Synthesis of Novel 6-O-phosphorylated 6-Hydroxypyridazine-3(2H)-one

Fifteen novel phosphonate derivatives containing a flavonoid unit were designed and synthesized, based on the connection method of active fragments. The target compounds were characterized by 1H NM...

Synthesis and antibacterial activity of novel phosphorylated flavonoid derivatives

4-O-phosphorylated paeonol derivatives were conveniently prepared by a facile method. Resacetophenone was prepared by the Friedel–Crafts acylation reaction of acetic acid with resorcinol. It was then phosphorylated regioselectively at the 4-O position using the Atherton–Todd reaction. An efficient, highly regioselective method to synthesize 4-O-phosphorylated paeonol derivatives is provided, and the approach has the merits of mild reaction conditions. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.

Highly Regioselective Synthesis of Novel 4-O-Phosphorylated Paeonol Analogs

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Highly Regioselective Synthesis of Novel 4-O-Phosphorylated Paeonol Analogs