Feng Sun
Shanghai Jiao Tong University
28 Papers
28 Citations
Feng Sun is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Congenital hypothyroidism & Thyroid. The author has an hindex of 6, co-authored 20 publications.
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Papers
The genetic characteristics of congenital hypothyroidism in China by comprehensive screening of 21 candidate genes.
Feng Sun,Jun-Xiu Zhang,Chang-Yi Yang,Guan-Qi Gao,Wen-Bin Zhu,Bing Han,Lele Zhang,Yue-Yue Wan,Xiao-Ping Ye,Yu-Ru Ma,Man-Man Zhang,Liu Yang,Qian-Yue Zhang,Wei Liu,Cui-Cui Guo,gang Chen,Shuang-Xia Zhao,Ke-Yi Song,Huai-Dong Song +18 more
TL;DR: Most cases of congenital hypothyroidism in China were caused by thyroid dyshormonogenesis rather than thyroid dysgenesis, and DUOX2 was the most frequently mutated gene in these patients, which was significantly different from Western countries.
93
Mutation screening of the TSHR gene in 220 Chinese patients with congenital hypothyroidism.
Ya Fang,Feng Sun,Rui-Jia Zhang,Chang-Run Zhang,Chen-Yan Yan,Zheng Zhou,Qian-Yue Zhang,Lu Li,Ying-Xia Ying,Shuang-Xia Zhao,Jun Liang,Huai-Dong Song,Huai-Dong Song +12 more
TL;DR: One novel TSHR variant was found and four genetic alterations revealed important role of the Ile216, Ala275, Asn372, Ser567 residues in signaling.
22
Genetic Study in a Large Cohort Supported Different Pathogenesis of Graves' Disease and Hashimoto's Hypothyroidism.
Qian-Yue Zhang,Wei Liu,Lu Li,Wen-Hua Du,Chun-Lin Zuo,Xiao-Ping Ye,Zheng Zhou,Fei-Fei Yuan,Yu-Ru Ma,Feng Sun,Sha-Sha Yu,Hui-Jun Xie,Chang-Run Zhang,Ying-Xia Ying,Guoyue Yuan,Guan-Qi Gao,Jun Liang,Shuang-Xia Zhao,Huai-Dong Song +18 more
TL;DR: The findings suggested that the pathogenesis of HT and GD was different, with six susceptibility loci with heterogeneity between GD and HT and four loci associated with GD, but not with HT including HLA-DPB1, CD40, TSHR and TG.
22
Upregulation of GBP1 in thyroid primordium is required for developmental thyroid morphogenesis.
Ruimeng Yang,Ming Zhan,Qin-Yi Zhou,Xiao-Ping Ye,Feng-Yao Wu,Mei Dong,Feng Sun,Ya Fang,Rui-Jia Zhang,Chang-Run Zhang,Liu Yang,Miaomiao Guo,Jun-Xiu Zhang,Jun Liang,Feng Cheng,Wei Liu,Bing Han,Yi Zhou,Shuang-Xia Zhao,Huai-Dong Song +19 more
TL;DR: In this paper, four pathogenic GBP1 variations from three patients were identified and the functions of the identified variants were confirmed using thyroid epithelial cells in vitro and in zebrafish model organisms in vivo.
18
The TPO mutation screening and genotype-phenotype analysis in 230 Chinese patients with congenital hypothyroidism
Rui-Jia Zhang,Feng Sun,Feng Chen,Ya Fang,Chen-Yan Yan,Chang-Run Zhang,Ying-Xia Ying,Zheng Wang,Cao-Xu Zhang,Feng-Yao Wu,Bing Han,Jun Liang,Shuang-Xia Zhao,Huai-Dong Song +13 more
TL;DR: The findings indicated that the residual enzymatic activity of TPO was correlated with clinical phenotypes of CH patients with TPO biallelic mutations.
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