Feng Peng
8 Papers
2 Citations
Feng Peng is an academic researcher. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 2, co-authored 5 publications.
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Papers
A kinase-cGAS cascade to synthesize a therapeutic STING activator
John A. McIntosh,Zhijian Liu,Brian M. Andresen,Nastaran Salehi Marzijarani,Jeffrey S. Moore,Nicholas M. Marshall,Margie Borra-Garske,Jennifer V. Obligacion,Patrick S. Fier,Feng Peng,Jacob Forstater,Matthew S. Winston,Chihui An,Wonsuk Chang,Jongwon Lim,Mark A. Huffman,Steven P. Miller,Fuh-Rong Tsay,Michael D. Altman,Charles A. Lesburg,Dietrich Steinhuebel,B. Wesley Trotter,Jared N. Cumming,Alan B. Northrup,Xiaodong Bu,Benjamin F. Mann,Mirlinda Biba,Kaori Hiraga,Grant S. Murphy,Joshua N. Kolev,Amanda M. Makarewicz,Weilan Pan,Iman Farasat,Rachel S Bade,Kevin Stone,Da Duan,Oscar Alvizo,Donovan Adpressa,Erik D. Guetschow,Erik Hoyt,Erik L. Regalado,Steve Castro,Nelo R. Rivera,Joseph P. Smith,Fengqiang Wang,Alejandro Crespo,Deeptak Verma,Stephanus Axnanda,Zachary E.X. Dance,Paul N. Devine,David M. Tschaen,Keith Canada,Paul G. Bulger,Benjamin D. Sherry,Matthew D. Truppo,Rebecca T. Ruck,L.-C. Campeau,David Jonathan Bennett,Guy R. Humphrey,Kevin R. Campos,Matthew L. Maddess +60 more
TL;DR: The substantial capacity that currently exists to use biosynthetic approaches to discover and manufacture complex, non-natural molecules is demonstrated.
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A Unified Strategy to Fluorinated Nucleoside Analogues Via an Electrophilic Manifold.
Andrew J. Neel,Ben W. H. Turnbull,William P. Carson,Tamas Benkovics,Cheol K. Chung,Heather C. Johnson,Zhuqing Liu,Feng Peng,Stephan M. Rummelt,Zhiguo J. Song,Lushi Tan,Lu Wang,Feng Xu +12 more
TL;DR: The utility of the 2'-ketonucleoside synthon as a platform for further diversification is demonstrated and it is suggested that this methodology should be broadly applicable to the discovery of novel nucleoside analogues.
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pH-Switchable Phase-Transfer Agents for Host Cell Protein Rejection in the Cascaded Biocatalytic Synthesis of an Active Pharmaceutical Ingredient
Matthew S. Winston,Marc-Andre Poirier,Zhijian Liu,Feng Peng,Guy R. Humphrey,John A. McIntosh,Mikhail Reibarkh,Fengqiang Wang,Erik D. Guetschow,Steve Castro,Erik Hoyt,David J. Lamberto,Kevin Sirk +12 more
- 22 Dec 2022
TL;DR: In this article , a pH-responsive extraction strategy using tertiary ammonium phase-transfer agents for efficient purification and isolation of hydrophilic immuno-oncology drug candidate MK-1454 from an aqueous biocatalytic cascade containing crude E. coli cell lysates is presented.
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Development of a Kilogram-Scale Synthesis of a Key Ulevostinag Subunit Part I: Accessing a Keto-Nucleoside Intermediate from Guanosine
Ben W. H. Turnbull,Feng Peng,Andrew J. Neel,Tamas Benkovics,Zhuqing Liu,Cheol K. Chung,Zhiguo J. Song,Lushi Tan,Khateeta M. Emerson,Chengqian Xiao,Yi Zhang,Benjamin D. Sherry +11 more
TL;DR: In this paper , a kilogram-scale synthesis of a key fragment of Ulevostinag (MK-1454), a cyclic dinucleotide agonist of the stimulator of interferon genes (STING), is described.
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Direct Enol Ether Metalation–Negishi Coupling Strategy To Prepare α-Heteroaryl Enol Ethers
Feng Peng,Kailin Liu,Huangguang Zhang,Fuchun Xu,Yanan Liu,Gao Shang +5 more
TL;DR: A direct enol ether metalation-Negishi coupling strategy is developed, utilizing palladium-Cy-DPEPhos catalysis, to synthesize α-heteroaryl enol ethers with broad substrate scope, complementing existing Heck coupling methods for challenging α-heteroaryl-α-alkoxy alkenes synthesis.
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