Feng Huang
University of California, Los Angeles
8 Papers
174 Citations
Feng Huang is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Epitope & Peptide. The author has an hindex of 7, co-authored 8 publications.
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Papers
•Journal Article
Clues to pathogenesis of spondyloarthropathy derived from synovial fluid mononuclear cell gene expression profiles.
Jieruo Gu,Markus Rihl,Elisabeth Märker-Hermann,Dominique Baeten,Jens G. Kuipers,Yeong Wook Song,Walter P. Maksymowych,Ruben Burgos-Vargas,Eric Veys,Filip De Keyser,Helmuth Deister,Momiao Xiong,Feng Huang,Wen Chan Tsai,David T. Y. Yu +14 more
TL;DR: The patient derived data suggest that it also occurs in vivo in the macrophages of SpA joints, which is compatible with the UPR hypothesis.
83
Induction of alternative splicing of HLA-B27 by bacterial invasion.
Feng Huang,Akihiro Yamaguchi,Naoyuki Tsuchiya,Takashi Ikawa,Naoto Tamura,Mika Virtala,Kaisa Granfors,Parvin M. Yasaei,David T. Y. Yu,David T. Y. Yu +9 more
TL;DR: The association between arthritis-causing bacteria and HLA-B27 positive cells is a complex event and Soluble HLA -B27 is a potential key player.
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•Journal Article
The effect of mutant beta 2-microglobulins on the conformation of HLA-B27 detected by antibody and by CTL.
Toru Fukazawa,Elisabeth Hermann,Michael Edidin,Juan Wen,Feng Huang,Herbert Kellner,Jürgen Floege,Danny Farahmandian,Kristina M. Williams,David T. Y. Yu +9 more
TL;DR: Results indicate that certain beta 2-m residues play an indirect role in peptide presentation, although they are not directly associated with the peptide residues.
22
A patient-derived cytotoxic T-lymphocyte clone and two peptide-dependent monoclonal antibodies recognize HLA-B27-peptide complexes with low stringency for peptide sequences.
Feng Huang,E Hermann,Jeffrey C. Wang,X. K. Cheng,W C Tsai,Juan Wen,Jens G. Kuipers,Herbert Kellner,B Ackermann,G. Roth,K M Williams,D K Yu,R B Raybourne +12 more
TL;DR: Results indicate that immune recognition of HLA-B27-peptide complexes might have rather low stringency for the peptide sequences, in theory, pathogen-derived peptides which induce autoimmunity by generating autoreactive CTL might not share much sequence similarity with the responsible self peptides.
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•Journal Article
Testing the importance of each residue in a HLA-B27-binding peptide using monoclonal antibodies.
Toru Fukazawa,Jun Wang,Feng Huang,Juan Wen,D Tyan,Kristina M. Williams,R. B. Raybourne,David T. Y. Yu +7 more
TL;DR: Experiments showed that in P4, P5, P6, P7, P8, and P9, all 20 different amino acids could be substituted without eliminating the ability of the analogues to bind to HLA-B27.
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