Feng He
Chinese Academy of Sciences
18 Papers
193 Citations
Feng He is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Drosophila embryogenesis & Morphogen. The author has an hindex of 10, co-authored 13 publications. Previous affiliations of Feng He include Zhejiang University & Cincinnati Children's Hospital Medical Center.
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Papers
CAF-1 is essential for Drosophila development and involved in the maintenance of epigenetic memory
Yanjun Song,Feng He,Feng He,Gengqiang Xie,Gengqiang Xie,Xiaoyan Guo,Yanjuan Xu,Yixu Chen,Xuehong Liang,Igor Stagljar,Dieter Egli,Jun Ma,Renjie Jiao +12 more
TL;DR: It is established that dCAF-1-p180 is an essential gene for Drosophila development and the importance of dCAf-1 in regulating gene expression and DNA repair in vivo is further underscore.
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Shaping a Morphogen Gradient for Positional Precision
Feng He,Feng He,Timothy E. Saunders,Ying Wen,David Cheung,Renjie Jiao,Pieter Rein ten Wolde,Martin Howard,Jun Ma +8 more
TL;DR: It is demonstrated that noise in the Bcd input signal is dominated by internal fluctuations but, due to time and spatial averaging, the spatial precision of the Hb boundary is primarily affected by embryo-to-embryo variations.
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Distance measurements via the morphogen gradient of Bicoid in Drosophila embryos
TL;DR: The findings described in this report provide a first quantitative, experimental evaluation of embryo geometry on Bcd gradient formation and target responses and demonstrate that the physical features of an embryo, such as its shape, are integral to how pattern is formed.
A multiscale investigation of bicoid-dependent transcriptional events in Drosophila embryos.
TL;DR: This study represents a first experimental uncovering of the actions of BCD in controlling the actual transcriptional events while its positional information is decoded during development, establishing a sustained role of Bcd in transcriptional decisions of individual copies of its target genes to generate sharp expression boundaries.
Morphogen gradient formation and action: insights from studying Bicoid protein degradation.
Junbo Liu,Feng He,Jun Ma +2 more
TL;DR: An estimate of BCD half-life, <15 min, in embryos during the time of gradient formation is described, and the role of Bcd-encoded positional information in controlling the positioning and precision of developmental decisions is discussed.
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