Feng Guo
Nanchang University
9 Papers
Feng Guo is an academic researcher from Nanchang University. The author has contributed to research in topics: Chemistry & Bioavailability. The author has an hindex of 4, co-authored 7 publications.
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Papers
Enhanced oral bioavailability of insulin using PLGA nanoparticles co-modified with cell-penetrating peptides and Engrailed secretion peptide (Sec)
Siqi Zhu,Shuangxi Chen,Yuan Gao,Feng Guo,Fengying Li,Baogang Xie,Jianliang Zhou,Haijun Zhong +7 more
TL;DR: Using insulin as the model drug, in vivo studies performed on rats indicated that the relative bioavailability of insulin for Sec-Pen-NPs was 1.71-times increased after ileal segments administration, and stronger hypoglycemic effects was also observed, suggesting the nanoparticles co-modified with penetratin and Sec could act as attractive carriers for oral delivery of insulin.
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Self-microemulsifying Drug Delivery System for Improved Oral Bioavailability of Dipyridamole: Preparation and Evaluation
TL;DR: It was evident that SMEDDS may be an effective approach to improve the oral absorption for drugs having pH-dependent solubility.
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Curcumin-loaded hydroxypropyl-β-cyclodextrin inclusion complex with enhanced dissolution and oral bioavailability for epilepsy treatment
TL;DR: A simple and reproducible strategy to effectively improve the bioavailability and therapeutic effects of curcumin, which could be potentially used in epilepsy treatment is shown.
11
Targeted delivery of pexidartinib to tumor-associated macrophages via legumain-sensitive dual-coating nanoparticles for cancer immunotherapy.
Desheng Liang,Weiliang You,Fang-Fang Zhu,Jia-Hui Wang,Feng Guo,Jian-Jun Xu,Xin-Liang Liu,Haijun Zhong +7 more
TL;DR: In this article , a legumain-sensitive dual-coating nanosystem (s-Tpep-NPs) was employed to deliver CSF-1R inhibitor pexidartinib (PLX3397) for targeting TAM therapy.
8
Legumain protease-sheddable PEGylated, tuftsin-modified nanoparticles for selective targeting to tumor-associated macrophages
De-Sheng Liang,Zu-Jun Wen,Jia-Hui Wang,Fang-Fang Zhu,Feng Guo,Jianliang Zhou,Jianjun Xu,Haijun Zhong +7 more
TL;DR: In this paper, the authors constructed a novel tumor-associated macrophage (TAM) target for anticancer therapy, which is an attractive cell target for antimalignancy therapy.
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