76 Papers
733 Citations
Feng Gao is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Reperfusion injury & Transplantation. The author has an hindex of 36, co-authored 73 publications. Previous affiliations of Feng Gao include Humboldt University of Berlin.
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Papers
Toll-like receptor and heme oxygenase-1 signaling in hepatic ischemia/reperfusion injury.
Xiu-Da Shen,Bibo Ke,Yuan Zhai,Feng Gao,Ronald W. Busuttil,Genhong Cheng,Jerzy W. Kupiec-Weglinski +6 more
TL;DR: In conclusion, this study highlights the importance of cross talk between HO‐1 and TLR system in the mechanism of hepatic IRI, which represents a case for innate immunity in which HO‐ 1 modulates proinflammatory responses that are triggered via TLR4 signaling, a putativeHO‐1 repressor.
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KEAP1-NRF2 complex in ischemia-induced hepatocellular damage of mouse liver transplants.
Bibo Ke,Xiu Da Shen,Yu Zhang,Haofeng Ji,Feng Gao,Shi Yue,Naoko Kamo,Yuan Zhai,Masayuki Yamamoto,Ronald W. Busuttil,Jerzy W. Kupiec-Weglinski +10 more
TL;DR: Keap1-Nrf2 complex prevents oxidative injury in IR-stressed OLTs through Keap1 signaling, which negatively regulates Nrf2 pathway.
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Heme oxygenase 1 gene transfer prevents CD95/Fas ligand-mediated apoptosis and improves liver allograft survival via carbon monoxide signaling pathway.
Bibo Ke,Roland Buelow,Xiu-Da Shen,Judy Melinek,Farin Amersi,Feng Gao,Thomas Ritter,Hans-Dieter Volk,Ronald W. Busuttil,Jerzy W. Kupiec-Weglinski +9 more
TL;DR: Ad-HO-1 gene transfer prevents CD95/FasL-mediated apoptosis, and significantly prolongs allogeneic OLT survival via a downstream HO-1-CO signaling pathway.
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CD154-CD40 T-cell costimulation pathway is required in the mechanism of hepatic ischemia/reperfusion injury, and its blockade facilitates and depends on heme oxygenase-1 mediated cytoprotection
Xiu-Da Shen,Bibo Ke,Yuan Zhai,Farin Amersi,Feng Gao,Dean M. Anselmo,Ronald W. Busuttil,Jerzy W. Kupiec-Weglinski +7 more
TL;DR: This study confirms the importance of T cells, and documents for the first time the role of CD154 costimulation signals in the mechanism of hepatic I/R injury, and shows that CD154 blockade-mediated cytoprotection results and depends on HO-1 overexpression.
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Absence of toll-like receptor 4 (TLR4) signaling in the donor organ reduces ischemia and reperfusion injury in a murine liver transplantation model.
Xiu-Da Shen,Bibo Ke,Yuan Zhai,Feng Gao,Sei-ichiro Tsuchihashi,Charles Lassman,Ronald W. Busuttil,Jerzy W. Kupiec-Weglinski +7 more
TL;DR: The rationale to locally modify innate TLR4 signaling in the donor organ to more efficiently control the adaptive posttransplantation IRI‐dependent responses is provided.
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