21 Papers
41 Citations
Feng Chi is an academic researcher from University of Southern California. The author has contributed to research in topics: Vimentin & Blood–brain barrier. The author has an hindex of 14, co-authored 21 publications. Previous affiliations of Feng Chi include Children's Hospital Los Angeles.
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Papers
NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation
TL;DR: It is shown that NOTCH1 promotes reprogramming of mitochondrial metabolism for M1 macrophage activation and inhibition of the NOTCH pathway or Pdp1 knockdown abrogated glucose oxidation, mtROS, and M1 gene expression.
Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6
Keane K. Y. Lai,Soo-Mi Kweon,Feng Chi,Edward Hwang,Yasuaki Kabe,Reiichi Higashiyama,Lan Qin,Rui Yan,Raymond Wu,Keith Lai,Naoaki Fujii,Samuel W. French,Samuel W. French,Jun Xu,Jian Ying Wang,Ramachandran Murali,Ramachandran Murali,Lopa Mishra,Ju Seog Lee,James M. Ntambi,Hidekazu Tsukamoto,Hidekazu Tsukamoto +21 more
TL;DR: In rodent HSCs and TICs, SCD expression was found to be regulated by Wnt-β-catenin signaling, and MUFAs produced by SCD provided a forward loop to amplify Wnt signaling via stabilization of Lrp5 and LRp6 mRNAs, contributing to liver fibrosis and tumor growth.
152
Circulating Brain Microvascular Endothelial Cells (cBMECs) as Potential Biomarkers of the Blood–Brain Barrier Disorders Caused by Microbial and Non-Microbial Factors
Sheng-He Huang,Sheng-He Huang,Lin Wang,Lin Wang,Feng Chi,Chun-Hua Wu,Hong Cao,Aimin Zhang,Ambrose Jong +8 more
TL;DR: Results demonstrated that cBMECs as well as EPCs may be used as potential cell-based biomarkers for indexing of BBB injury and plays an important role in CNS inflammation and BBB disorders caused by microbial and non-microbial factors.
Vimentin and PSF act in concert to regulate IbeA+ E. coli K1 induced activation and nuclear translocation of NF-κB in human brain endothelial cells.
TL;DR: It is suggested that vimentin and PSF cooperatively contribute to IbeA-induced cytoplasmic activation and nuclear translocation of NF-κB activation and may represent a new paradigm in pathogen-induced signal transduction and lead to the development of novel strategies for the prevention and treatment of bacterial meningitis.
41
Meningitic Escherichia coli K1 Penetration and Neutrophil Transmigration Across the Blood–Brain Barrier are Modulated by Alpha7 Nicotinic Receptor
Feng Chi,Lin Wang,Lin Wang,Xueye Zheng,Chun-Hua Wu,Ambrose Jong,Michael A. Sheard,Wei Shi,Sheng-He Huang +8 more
TL;DR: The data suggest that α7 nAChR plays a detrimental role in the host defense against meningitic infection by modulation of pathogen invasion, PMN recruitment, calcium signaling and neuronal inflammation.