Feng Cheng
6 Papers
Feng Cheng is an academic researcher. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 1, co-authored 1 publications.
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Papers
Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human
Huai-Dong Song,Chang-Chun Tu,Guo-Wei Zhang,Shengyue Wang,Kui Zheng,Lian-Cheng Lei,Qiu-Xia Chen,Yu-Wei Gao,Hui-Qiong Zhou,Hua Xiang,Hua-Jun Zheng,Shur-Wern Wang Chern,Feng Cheng,Chun-Ming Pan,Hua Xuan,Sai-Juan Chen,Hui-Ming Luo,Duan-Hua Zhou,Yu-Fei Liu,Jian-Feng He,Peng-Zhe Qin,Ling-Hui Li,Yu-Qi Ren,Wen-Jia Liang,Ye-Dong Yu,Larry J. Anderson,Ming Wang,Rui-Heng Xu,Xin-Wei Wu,Huan-Ying Zheng,Jin-Ding Chen,Guodong Liang,Yang Gao,Ming Liao,Ling Fang,Li-Yun Jiang,Hui Li,Fang Chen,Biao Di,Li-Juan He,Jin-Yan Lin,Suxiang Tong,Xiangang Kong,Lin Du,Pei Hao,Hua Tang,Andrea Bernini,Xiao-Jing Yu,Ottavia Spiga,Zong-Ming Guo,Hai-Yan Pan,Wei-Zhong He,Jean-Claude Manuguerra,Arnaud Fontanet,Antoine Danchin,Neri Niccolai,Yixue Li,Chung-I Wu,Guoping Zhao +58 more
TL;DR: The ratio of nonsynonymous/synonymous nucleotide substitution in palm civets collected 1 yr apart from different geographic locations is very high, suggesting a rapid evolving process of viral proteins in civet as well, much like their adaptation in the human host in the early 2002-2003 epidemic.
760
Pathogenic variations in MAML2 and MAMLD1 contribute to congenital hypothyroidism due to dyshormonogenesis by regulating the Notch signalling pathway
Feng-Yao Wu,Ruimeng Yang,Hai Yang Zhang,Ming Zhan,Ping Tu,Cao-Xu Zhang,Mei Dong,Ren-Jie Cui,Xiao Yu Liu,Liu Yang,Chen-Yan Yan,Feng Sun,Zheng Wang,Jun Liang,Huai-Dong Song,Feng Cheng +15 more
TL;DR: In this article , the authors identified three mastermind-like family gene variants in CH and revealed that both canonical and non-canonical Notch signalling affected thyroid hormone biosynthesis, and these three variants blocked the expression of genes associated with thyroid thyroid biosynthesis.
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Genetic screening and functional analysis of TPO variants in Chinese patients with congenital hypothyroidism.
Hai Yang Zhang,Xue-Song Li,Cao-Xu Zhang,Ping Tu,Ruimeng Yang,Xiao Yu Liu,Ren-Jie Cui,Liu Yang,Chen-Yang Wu,Rui-Jia Zhang,Ya Fang,Feng Sun,Jun Liang,Feng Cheng,Huai-Dong Song,Shuang-Xia Zhao +15 more
TL;DR: It is determined that a residual TPO enzyme activity threshold of 15% may serve as a criterion for differentiating CH severity, and relationships between TPO genotypes and clinical characteristics are established.
1
Contactin 6, A Novel Causative Gene for Congenital Hypothyroidism, Mediates Thyroid Hormone Biosynthesis through Notch Signaling.
Hai Yang Zhang,Feng-Yao Wu,Cao-Xu Zhang,Chen-Yang Wu,Ren-Jie Cui,Xiao Yu Liu,Liu Yang,Yue Zhang,Feng Sun,Feng Cheng,Ruimeng Yang,Huai-Dong Song,Shuang-Xia Zhao +12 more
TL;DR: This study demonstrated that CNTN6 is a novel causative gene for CH through the mediation of thyroid hormone biosynthesis via Notch signaling, which provides new insights into the genetic background and mechanisms involved in CH and thyroid dyshormonogenesis.
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[Genetic mutation profiles for children with congenital hypothyroidism in Fujian province].
TL;DR: Wang et al. as discussed by the authors explored the mutation characteristics of pathogenic genes in children with congenital hypothyroidism (CH) in Fujian, using targeted exome sequencing technology to detect the mutation frequency, type and distribution characteristics of 29 genes related to thyroid development.